PKNOX2 (PBX/knotted 1 homeobox 2)

2021-06-01 Affiliation

Identity

HGNC

PKNOX2

LOCATION

11q24.2

LOCUSID

63876

ALIAS

PREP2

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 63876
MIM: 613066
HGNC: 16714
Ensembl: ENSG00000165495

Variants:

dbSNP: 63876
ClinVar: 63876
TCGA: ENSG00000165495
COSMIC: PKNOX2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000165495	ENST00000298282	Q96KN3
ENSG00000165495	ENST00000527238	E9PKL2
ENSG00000165495	ENST00000531212	E9PRB6
ENSG00000165495	ENST00000532623	E9PQS4
ENSG00000165495	ENST00000558705	H0YLX0

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
38644381	2024	PBX/Knotted 1 homeobox-2 (PKNOX2) is a novel regulator of myocardial fibrosis.	0
38644381	2024	PBX/Knotted 1 homeobox-2 (PKNOX2) is a novel regulator of myocardial fibrosis.	0
30515693	2019	PKNOX2 expression and regulation in the bone marrow mesenchymal stem cells of Fanconi anemia patients and healthy donors.	2
30745575	2019	PKNOX2 suppresses gastric cancer through the transcriptional activation of IGFBP5 and p53.	20
30515693	2019	PKNOX2 expression and regulation in the bone marrow mesenchymal stem cells of Fanconi anemia patients and healthy donors.	2
30745575	2019	PKNOX2 suppresses gastric cancer through the transcriptional activation of IGFBP5 and p53.	20
22648509	2012	PKNOX2 is associated with formal thought disorder in schizophrenia: a meta-analysis of two genome-wide association studies.	11
22648509	2012	PKNOX2 is associated with formal thought disorder in schizophrenia: a meta-analysis of two genome-wide association studies.	11
21298047	2011	The nuclear transcription factor PKNOX2 is a candidate gene for substance dependence in European-origin women.	21
21298047	2011	The nuclear transcription factor PKNOX2 is a candidate gene for substance dependence in European-origin women.	21
20379614	2010	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.	78
20628086	2010	Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.	15
20379614	2010	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.	78
20628086	2010	Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.	15
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	105

Citation

Dessen P

PKNOX2 (PBX/knotted 1 homeobox 2)

Atlas Genet Cytogenet Oncol Haematol. 2021-06-01

Online version: http://atlasgeneticsoncology.org/gene/58166/pknox2-(pbx-knotted-1-homeobox-2)