TAS2R4 (taste 2 receptor member 4)

2021-06-01  

Identity

HGNC
LOCATION
7q34
LOCUSID
ALIAS
T2R4

Other Information

Locus ID:

NCBI: 50832
MIM: 604869
HGNC: 14911
Ensembl: ENSG00000127364

Variants:

dbSNP: 50832
ClinVar: 50832
TCGA: ENSG00000127364
COSMIC: TAS2R4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000127364ENST00000247881Q9NYW5

Expression (GTEx)

0
5
10
15

Pathways

PathwaySourceExternal ID
Taste transductionKEGGko04742
Taste transductionKEGGhsa04742
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class C/3 (Metabotropic glutamate/pheromone receptors)REACTOMER-HSA-420499
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594

References

Pubmed IDYearTitleCitations
387326072024Differential Activation of TAS2R4 May Recover Ability to Taste Propylthiouracil for Some TAS2R38 AVI Homozygotes.0
387326072024Differential Activation of TAS2R4 May Recover Ability to Taste Propylthiouracil for Some TAS2R38 AVI Homozygotes.0
335722252021Genetic Variation in the Bitter Receptors Responsible for Epicatechin Detection Are Associated with BMI in an Elderly Cohort.3
335722252021Genetic Variation in the Bitter Receptors Responsible for Epicatechin Detection Are Associated with BMI in an Elderly Cohort.3
318945292020Chemosensory bitter taste receptors T2R4 and T2R14 activation attenuates proliferation and migration of breast cancer cells.16
321592112020Bitter receptor member TAS2R4 may have neurobiological function beyond acting as a bitter receptor.2
318945292020Chemosensory bitter taste receptors T2R4 and T2R14 activation attenuates proliferation and migration of breast cancer cells.16
321592112020Bitter receptor member TAS2R4 may have neurobiological function beyond acting as a bitter receptor.2
303019232018Genetic variations in TAS2R3 and TAS2R4 bitterness receptors modify papillary carcinoma risk and thyroid function in Korean females.10
303019232018Genetic variations in TAS2R3 and TAS2R4 bitterness receptors modify papillary carcinoma risk and thyroid function in Korean females.10
278731432017Regulation of Rac1 GTPase activity by quinine through G-protein and bitter taste receptor T2R4.3
278731432017Regulation of Rac1 GTPase activity by quinine through G-protein and bitter taste receptor T2R4.3
272888922016Cholesterol modulates bitter taste receptor function.8
272888922016Cholesterol modulates bitter taste receptor function.8
258447972015Abscisic Acid Acts as a Blocker of the Bitter Taste G Protein-Coupled Receptor T2R4.11

Citation

Dessen P

TAS2R4 (taste 2 receptor member 4)

Atlas Genet Cytogenet Oncol Haematol. 2021-06-01

Online version: http://atlasgeneticsoncology.org/gene/58179/tas2r4-(taste-2-receptor-member-4)