ADGRL1 (adhesion G protein-coupled receptor L1)

2021-06-01  

Identity

HGNC
LOCATION
19p13.12
LOCUSID
ALIAS
CIRL1,CL1,LEC2,LPHN1

Other Information

Locus ID:

NCBI: 22859
MIM: 616416
HGNC: 20973
Ensembl: ENSG00000072071

Variants:

dbSNP: 22859
ClinVar: 22859
TCGA: ENSG00000072071
COSMIC: ADGRL1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000072071ENST00000340736O94910
ENSG00000072071ENST00000361434O94910
ENSG00000072071ENST00000589616K7ESH3
ENSG00000072071ENST00000592164K7EK47
ENSG00000072071ENST00000593005K7ERC3

Expression (GTEx)

0
50
100
150

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
304575532018Proteolytically released Lasso/teneurin-2 induces axonal attraction by interacting with latrophilin-1 on axonal growth cones.9
273222122016Expression of functional neuronal receptor latrophilin 1 in human acute myeloid leukaemia cells.5
273257522017Latrophilin receptors: novel bronchodilator targets in asthma.3
209710622010Association of the subunits of the calcium-independent receptor of α-latrotoxin.2
264857512015Role of the teneurins, teneurin C-terminal associated peptides (TCAP) in reproduction: clinical perspectives.2
299078812018Cortisol facilitates the immune escape of human acute myeloid leukemia cells by inducing latrophilin 1 expression.2
299386812018Overexpression of the ABCB1 drug transporter in acute myeloid leukemia cells is associated with downregulation of latrophilin-1.1
313395862019Alternative splicing event modifying ADGRL1/latrophilin-1 cytoplasmic tail promotes both opposing and dual cAMP signaling pathways.0

Citation

Dessen P

ADGRL1 (adhesion G protein-coupled receptor L1)

Atlas Genet Cytogenet Oncol Haematol. 2021-06-01

Online version: http://atlasgeneticsoncology.org/gene/58193/adgrl1-(adhesion-g-protein-coupled-receptor-l1)