ADGRL1 (adhesion G protein-coupled receptor L1)

2021-06-01  

Identity

HGNC
ADGRL1
LOCATION
19p13.12
LOCUSID
22859
ALIAS
CIRL1,CL1,LEC2,LPHN1

Other Information

Locus ID:

NCBI: 22859
MIM: 616416
HGNC: 20973
Ensembl: ENSG00000072071

Variants:

dbSNP: 22859
ClinVar: 22859
TCGA: ENSG00000072071
COSMIC: ADGRL1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000072071ENST00000340736O94910
ENSG00000072071ENST00000361434O94910
ENSG00000072071ENST00000589616K7ESH3
ENSG00000072071ENST00000592164K7EK47
ENSG00000072071ENST00000593005K7ERC3

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
386643682024Dysfunction of the adhesion G protein-coupled receptor latrophilin 1 (ADGRL1/LPHN1) increases the risk of obesity.1
386643682024Dysfunction of the adhesion G protein-coupled receptor latrophilin 1 (ADGRL1/LPHN1) increases the risk of obesity.1
359074052022ADGRL1 haploinsufficiency causes a variable spectrum of neurodevelopmental disorders in humans and alters synaptic activity and behavior in a mouse model.11
359074052022ADGRL1 haploinsufficiency causes a variable spectrum of neurodevelopmental disorders in humans and alters synaptic activity and behavior in a mouse model.11
313395862019Alternative splicing event modifying ADGRL1/latrophilin-1 cytoplasmic tail promotes both opposing and dual cAMP signaling pathways.10
313395862019Alternative splicing event modifying ADGRL1/latrophilin-1 cytoplasmic tail promotes both opposing and dual cAMP signaling pathways.10
299078812018Cortisol facilitates the immune escape of human acute myeloid leukemia cells by inducing latrophilin 1 expression.6
299386812018Overexpression of the ABCB1 drug transporter in acute myeloid leukemia cells is associated with downregulation of latrophilin-1.5
304575532018Proteolytically released Lasso/teneurin-2 induces axonal attraction by interacting with latrophilin-1 on axonal growth cones.27
299078812018Cortisol facilitates the immune escape of human acute myeloid leukemia cells by inducing latrophilin 1 expression.6
299386812018Overexpression of the ABCB1 drug transporter in acute myeloid leukemia cells is associated with downregulation of latrophilin-1.5
304575532018Proteolytically released Lasso/teneurin-2 induces axonal attraction by interacting with latrophilin-1 on axonal growth cones.27
273257522017Latrophilin receptors: novel bronchodilator targets in asthma.6
273257522017Latrophilin receptors: novel bronchodilator targets in asthma.6
273222122016Expression of functional neuronal receptor latrophilin 1 in human acute myeloid leukaemia cells.7

Citation

Dessen P

ADGRL1 (adhesion G protein-coupled receptor L1)

Atlas Genet Cytogenet Oncol Haematol. 2021-06-01

Online version: http://atlasgeneticsoncology.org/gene/58193/adgrl1-(adhesion-g-protein-coupled-receptor-l1)