GRM8 (glutamate metabotropic receptor 8)

2021-06-01  

Identity

HGNC
LOCATION
7q31.33
LOCUSID
ALIAS
GLUR8,GPRC1H,MGLUR8,mGlu8

Other Information

Locus ID:

NCBI: 2918
MIM: 601116
HGNC: 4600
Ensembl: ENSG00000179603

Variants:

dbSNP: 2918
ClinVar: 2918
TCGA: ENSG00000179603
COSMIC: GRM8

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000179603ENST00000339582O00222
ENSG00000179603ENST00000341617O00222
ENSG00000179603ENST00000358373O00222
ENSG00000179603ENST00000412160C9J7I1
ENSG00000179603ENST00000444921A0A0A0MT06
ENSG00000179603ENST00000457830E7ETK3
ENSG00000179603ENST00000465844H7C4V5
ENSG00000179603ENST00000472701O00222

Expression (GTEx)

0
1
2
3
4

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
Glutamatergic synapseKEGGko04724
Glutamatergic synapseKEGGhsa04724
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class C/3 (Metabotropic glutamate/pheromone receptors)REACTOMER-HSA-420499
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594
Phospholipase D signaling pathwayKEGGko04072
Phospholipase D signaling pathwayKEGGhsa04072

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
330688162021Association between the group III metabotropic glutamate receptor gene polymorphisms and attention-deficit/hyperactivity disorder and functional exploration of risk loci.6
330688162021Association between the group III metabotropic glutamate receptor gene polymorphisms and attention-deficit/hyperactivity disorder and functional exploration of risk loci.6
322990012020GRM8 genotype is associated with externalizing disorders and greater inter-trial variability in brain activation during a response inhibition task.10
322990012020GRM8 genotype is associated with externalizing disorders and greater inter-trial variability in brain activation during a response inhibition task.10
303917812019Genomic sequencing and editing revealed the GRM8 signaling pathway as potential therapeutic targets of squamous cell lung cancer.21
303917812019Genomic sequencing and editing revealed the GRM8 signaling pathway as potential therapeutic targets of squamous cell lung cancer.21
302886432018TCF4 and GRM8 gene polymorphisms and risk of schizophrenia in an Iranian population: a case-control study.3
302886432018TCF4 and GRM8 gene polymorphisms and risk of schizophrenia in an Iranian population: a case-control study.3
278719132017What can time-frequency and phase coherence measures tell us about the genetic basis of P3 amplitude?6
278719132017What can time-frequency and phase coherence measures tell us about the genetic basis of P3 amplitude?6
266551902016Significant association of GRM7 and GRM8 genes with schizophrenia and major depressive disorder in the Han Chinese population.19
266551902016Significant association of GRM7 and GRM8 genes with schizophrenia and major depressive disorder in the Han Chinese population.19
248214062015A candidate syntenic genetic locus is associated with voluntary exercise levels in mice and humans.4
259788272015Further Analyses of Genetic Association Between GRM8 and Alcohol Dependence Symptoms Among Young Adults.7
248214062015A candidate syntenic genetic locus is associated with voluntary exercise levels in mice and humans.4

Citation

Dessen P

GRM8 (glutamate metabotropic receptor 8)

Atlas Genet Cytogenet Oncol Haematol. 2021-06-01

Online version: http://atlasgeneticsoncology.org/gene/58253/grm8-(glutamate-metabotropic-receptor-8)