Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 57449
MIM: 611101
HGNC: 29105
Ensembl: ENSG00000171680
Variants:
dbSNP: 57449
ClinVar: 57449
TCGA: ENSG00000171680
COSMIC: PLEKHG5
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 35639414 | 2022 | Characterization and computational simulation of human Syx, a RhoGEF implicated in glioblastoma. | 1 |
| 35639414 | 2022 | Characterization and computational simulation of human Syx, a RhoGEF implicated in glioblastoma. | 1 |
| 33220101 | 2021 | Novel variants broaden the phenotypic spectrum of PLEKHG5-associated neuropathies. | 0 |
| 33220101 | 2021 | Novel variants broaden the phenotypic spectrum of PLEKHG5-associated neuropathies. | 0 |
| 33318498 | 2020 | PLEKHG5 regulates autophagy, survival and MGMT expression in U251-MG glioblastoma cells. | 6 |
| 33318498 | 2020 | PLEKHG5 regulates autophagy, survival and MGMT expression in U251-MG glioblastoma cells. | 6 |
| 31309383 | 2019 | PLEKHG5 is a novel prognostic biomarker in glioma patients. | 8 |
| 31309383 | 2019 | PLEKHG5 is a novel prognostic biomarker in glioma patients. | 8 |
| 23335514 | 2013 | Phosphorylation-mediated 14-3-3 protein binding regulates the function of the rho-specific guanine nucleotide exchange factor (RhoGEF) Syx. | 10 |
| 23777631 | 2013 | PLEKHG5 deficiency leads to an intermediate form of autosomal-recessive Charcot-Marie-Tooth disease. | 10 |
| 23844677 | 2013 | Mutations in the PLEKHG5 gene is relevant with autosomal recessive intermediate Charcot-Marie-Tooth disease. | 12 |
| 24126053 | 2013 | The Rho guanine nucleotide exchange factor Syx regulates the balance of dia and ROCK activities to promote polarized-cancer-cell migration. | 17 |
| 23335514 | 2013 | Phosphorylation-mediated 14-3-3 protein binding regulates the function of the rho-specific guanine nucleotide exchange factor (RhoGEF) Syx. | 10 |
| 23777631 | 2013 | PLEKHG5 deficiency leads to an intermediate form of autosomal-recessive Charcot-Marie-Tooth disease. | 10 |
| 23844677 | 2013 | Mutations in the PLEKHG5 gene is relevant with autosomal recessive intermediate Charcot-Marie-Tooth disease. | 12 |
Citation
Dessen P
PLEKHG5 (pleckstrin homology and RhoGEF domain containing G5)
Atlas Genet Cytogenet Oncol Haematol. 2021-06-01
Online version: http://atlasgeneticsoncology.org/gene/58298/meetings/case-report-explorer/
