ADK (adenosine kinase)

2003-11-01  

Identity

HGNC
ADK
LOCATION
10q22.2
LOCUSID
132
ALIAS
AK
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 132
MIM: 102750
HGNC: 257
Ensembl: ENSG00000156110

Variants:

dbSNP: 132
ClinVar: 132
TCGA: ENSG00000156110
COSMIC: ADK

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000156110ENST00000286621P55263
ENSG00000156110ENST00000372734P55263
ENSG00000156110ENST00000372734A0A140VJE0
ENSG00000156110ENST00000539909P55263
ENSG00000156110ENST00000541550P55263

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Purine metabolismKEGGko00230
Purine metabolismKEGGhsa00230
Metabolic pathwaysKEGGhsa01100
MetabolismREACTOMER-HSA-1430728
Metabolism of nucleotidesREACTOMER-HSA-15869
Purine metabolismREACTOMER-HSA-73847
Purine salvageREACTOMER-HSA-74217

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA448004abacavirChemicalPathwayassociated24625462

References

Pubmed IDYearTitleCitations
361818352023Hepatocyte Adenosine Kinase Promotes Excessive Fat Deposition and Liver Inflammation.4
361818352023Hepatocyte Adenosine Kinase Promotes Excessive Fat Deposition and Liver Inflammation.4
344791942022Genetic variations of adenosine kinase as predictable biomarkers of efficacy of vagus nerve stimulation in patients with pharmacoresistant epilepsy.7
344791942022Genetic variations of adenosine kinase as predictable biomarkers of efficacy of vagus nerve stimulation in patients with pharmacoresistant epilepsy.7
333090112021Adenosine kinase deficiency: Three new cases and diagnostic value of hypermethioninemia.6
333090112021Adenosine kinase deficiency: Three new cases and diagnostic value of hypermethioninemia.6
287894812017Upregulation of Neuronal Adenosine A1 Receptor in Human Rasmussen Encephalitis.8
287894812017Upregulation of Neuronal Adenosine A1 Receptor in Human Rasmussen Encephalitis.8
255751372015Adenosine kinase expression in cortical dysplasia with balloon cells: analysis of developmental lineage of cell types.10
260409192015Genetic variation in the adenosine regulatory cycle is associated with posttraumatic epilepsy development.28
263295392015Adenosine deaminase and adenosine kinase expression in human glioma and their correlation with glioma‑associated epilepsy.12
255751372015Adenosine kinase expression in cortical dysplasia with balloon cells: analysis of developmental lineage of cell types.10
260409192015Genetic variation in the adenosine regulatory cycle is associated with posttraumatic epilepsy development.28
263295392015Adenosine deaminase and adenosine kinase expression in human glioma and their correlation with glioma‑associated epilepsy.12
241286822013Upregulation of adenosine kinase in Rasmussen encephalitis.12

Citation

Dessen P

ADK (adenosine kinase)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/583/adk-(adenosine-kinase)