PLOD3 (procollagen-lysine,2-oxoglutarate 5-dioxygenase 3)

2021-06-01  

Identity

HGNC
LOCATION
7q22.1
LOCUSID
ALIAS
LH3

Other Information

Locus ID:

NCBI: 8985
MIM: 603066
HGNC: 9083
Ensembl: ENSG00000106397

Variants:

dbSNP: 8985
ClinVar: 8985
TCGA: ENSG00000106397
COSMIC: PLOD3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000106397ENST00000223127O60568
ENSG00000106397ENST00000414785C9JU11
ENSG00000106397ENST00000421736H7C2V1
ENSG00000106397ENST00000424135H7C2A8
ENSG00000106397ENST00000440925H7C0B8
ENSG00000106397ENST00000454310H7C2S8
ENSG00000106397ENST00000456079C9JIX5

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Lysine degradationKEGGko00310
Other types of O-glycan biosynthesisKEGGko00514
Lysine degradationKEGGhsa00310
Other types of O-glycan biosynthesisKEGGhsa00514
Extracellular matrix organizationREACTOMER-HSA-1474244
Collagen formationREACTOMER-HSA-1474290
Collagen biosynthesis and modifying enzymesREACTOMER-HSA-1650814

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
381845662024PLOD3 facilitated T cell activation in the colorectal tumor microenvironment and liver metastasis by the TNF-α/ NF-κB pathway.0
381845662024PLOD3 facilitated T cell activation in the colorectal tumor microenvironment and liver metastasis by the TNF-α/ NF-κB pathway.0
350396112022PLOD3 regulates the expression of YAP1 to affect the progression of non-small cell lung cancer via the PKCδ/CDK1/LIMD1 signaling pathway.2
364038582022Lysyl hydroxylase 3-mediated post-translational modifications are required for proper biosynthesis of collagen α1α1α2(IV).1
350396112022PLOD3 regulates the expression of YAP1 to affect the progression of non-small cell lung cancer via the PKCδ/CDK1/LIMD1 signaling pathway.2
364038582022Lysyl hydroxylase 3-mediated post-translational modifications are required for proper biosynthesis of collagen α1α1α2(IV).1
334835982021PLODs are overexpressed in ovarian cancer and are associated with gap junctions via connexin 43.8
337839892021COLGALT2 is overexpressed in ovarian cancer and interacts with PLOD3.7
339090262021Polypeptide N-acetylgalactosaminyltransferase 18 retains in endoplasmic reticulum depending on its luminal regions interacting with ER resident UGGT1, PLOD3 and LPCAT1.3
339847702021Involvement of LH3 and GLT25D1 for glucosyl-galactosyl-hydroxylation on non-collagen-like domain of FGL1.3
342399232021PLOD3 Is Associated with Immune Cell Infiltration and Genomic Instability in Colon Adenocarcinoma.5
343040932021Characterization of a cancer-associated Epstein-Barr virus EBNA1 variant reveals a novel interaction with PLOD1 and PLOD3.4
345760682021A Human Pan-Cancer System Analysis of Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase 3 (PLOD3).5
346462652021Integrated Profiling Identifies PLOD3 as a Potential Prognostic and Immunotherapy Relevant Biomarker in Colorectal Cancer.10
334835982021PLODs are overexpressed in ovarian cancer and are associated with gap junctions via connexin 43.8

Citation

Dessen P

PLOD3 (procollagen-lysine,2-oxoglutarate 5-dioxygenase 3)

Atlas Genet Cytogenet Oncol Haematol. 2021-06-01

Online version: http://atlasgeneticsoncology.org/gene/58323/submit-meetings/tumors-explorer/