SNRPA1 (small nuclear ribonucleoprotein polypeptide A)

2021-06-01  

Identity

HGNC
LOCATION
15q26.3
LOCUSID
ALIAS
Lea1,U2A

Other Information

Locus ID:

NCBI: 6627
MIM: 603521
HGNC: 11152
Ensembl: ENSG00000131876

Variants:

dbSNP: 6627
ClinVar: 6627
TCGA: ENSG00000131876
COSMIC: SNRPA1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000131876ENST00000254193P09661
ENSG00000131876ENST00000559309H0YKK0
ENSG00000131876ENST00000559686H0YMA0
ENSG00000131876ENST00000560496H0YLR3
ENSG00000131876ENST00000626000H0YKK0

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100

Pathways

PathwaySourceExternal ID
SpliceosomeKEGGko03040
SpliceosomeKEGGhsa03040
Spliceosome, U2-snRNPKEGGhsa_M00352
Spliceosome, U2-snRNPKEGGM00352
Gene ExpressionREACTOMER-HSA-74160
Processing of Capped Intron-Containing Pre-mRNAREACTOMER-HSA-72203
mRNA SplicingREACTOMER-HSA-72172
mRNA Splicing - Major PathwayREACTOMER-HSA-72163

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
367151822023Splicing factor SNRPA associated with microvascular invasion promotes hepatocellular carcinoma metastasis through activating NOTCH1/Snail pathway and is mediated by circSEC62/miR-625-5p axis.6
372771112023High SNRPA1 expression leads to poor prognosis in patients with lung adenocarcinoma.1
367151822023Splicing factor SNRPA associated with microvascular invasion promotes hepatocellular carcinoma metastasis through activating NOTCH1/Snail pathway and is mediated by circSEC62/miR-625-5p axis.6
372771112023High SNRPA1 expression leads to poor prognosis in patients with lung adenocarcinoma.1
334603992021Identification of RNA-binding protein SNRPA1 for prognosis in prostate cancer.4
339861532021A prometastatic splicing program regulated by SNRPA1 interactions with structured RNA elements.32
334603992021Identification of RNA-binding protein SNRPA1 for prognosis in prostate cancer.4
339861532021A prometastatic splicing program regulated by SNRPA1 interactions with structured RNA elements.32
324205852020mTOR up-regulation of SNRPA1 contributes to hepatocellular carcinoma development.6
324205852020mTOR up-regulation of SNRPA1 contributes to hepatocellular carcinoma development.6
312031322019An oncogenic gene, SNRPA1, regulates PIK3R1, VEGFC, MKI67, CDK1 and other genes in colorectal cancer.18
312031322019An oncogenic gene, SNRPA1, regulates PIK3R1, VEGFC, MKI67, CDK1 and other genes in colorectal cancer.18
285951162017The unique spliceosome signature of human pluripotent stem cells is mediated by SNRPA1, SNRPD1, and PNN.20
285951162017The unique spliceosome signature of human pluripotent stem cells is mediated by SNRPA1, SNRPD1, and PNN.20
248668162014Binding affinity and cooperativity control U2B″/snRNA/U2A' RNP formation.8

Citation

Dessen P

SNRPA1 (small nuclear ribonucleoprotein polypeptide A)

Atlas Genet Cytogenet Oncol Haematol. 2021-06-01

Online version: http://atlasgeneticsoncology.org/gene/58328/snrpa1-(small-nuclear-ribonucleoprotein-polypeptide-a)