OTUD5 (OTU deubiquitinase 5)

2021-06-01  

Identity

HGNC
LOCATION
Xp11.23
LOCUSID
ALIAS
DUBA,MCAND

Other Information

Locus ID:

NCBI: 55593
MIM: 300713
HGNC: 25402
Ensembl: ENSG00000068308

Variants:

dbSNP: 55593
ClinVar: 55593
TCGA: ENSG00000068308
COSMIC: OTUD5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000068308ENST00000156084Q96G74
ENSG00000068308ENST00000156084A0A024QZ09
ENSG00000068308ENST00000376488Q96G74
ENSG00000068308ENST00000396743Q96G74
ENSG00000068308ENST00000428668Q96G74
ENSG00000068308ENST00000455452H7BZQ3
ENSG00000068308ENST00000610466A0A087WXV6

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100

Pathways

PathwaySourceExternal ID
RIG-I-like receptor signaling pathwayKEGGko04622
RIG-I-like receptor signaling pathwayKEGGhsa04622
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathwaysREACTOMER-HSA-168928
Negative regulators of RIG-I/MDA5 signalingREACTOMER-HSA-936440
DeubiquitinationREACTOMER-HSA-5688426
Ovarian tumor domain proteasesREACTOMER-HSA-5689896

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
380360822024Hepatocyte Deubiquitinating Enzyme OTUD5 Deficiency is a Key Aggravator for Metabolic Dysfunction-Associated Steatohepatitis by Disturbing Mitochondrial Homeostasis.1
386589812024OTUD5 promotes the growth of hepatocellular carcinoma by deubiquitinating and stabilizing SLC38A1.0
380360822024Hepatocyte Deubiquitinating Enzyme OTUD5 Deficiency is a Key Aggravator for Metabolic Dysfunction-Associated Steatohepatitis by Disturbing Mitochondrial Homeostasis.1
386589812024OTUD5 promotes the growth of hepatocellular carcinoma by deubiquitinating and stabilizing SLC38A1.0
371900702023The Regulation and Double-Edged Roles of the Deubiquitinase OTUD5.4
381103692023Autophagy of OTUD5 destabilizes GPX4 to confer ferroptosis-dependent kidney injury.5
371900702023The Regulation and Double-Edged Roles of the Deubiquitinase OTUD5.4
381103692023Autophagy of OTUD5 destabilizes GPX4 to confer ferroptosis-dependent kidney injury.5
357659582022Mechanism of OTUD5 in non-small cell lung cancer cell proliferation, invasion, and migration.3
360852002022Deubiquitinase OTUD5 modulates mTORC1 signaling to promote bladder cancer progression.9
357659582022Mechanism of OTUD5 in non-small cell lung cancer cell proliferation, invasion, and migration.3
360852002022Deubiquitinase OTUD5 modulates mTORC1 signaling to promote bladder cancer progression.9
331102142021Deubiquitinase OTUD5 is a positive regulator of mTORC1 and mTORC2 signaling pathways.15
331310772021An X-linked syndrome with severe neurodevelopmental delay, hydrocephalus, and early lethality caused by a missense variation in the OTUD5 gene.11
334177622021Conformational Dynamics of Deubiquitinase A and Functional Implications.2

Citation

Dessen P

OTUD5 (OTU deubiquitinase 5)

Atlas Genet Cytogenet Oncol Haematol. 2021-06-01

Online version: http://atlasgeneticsoncology.org/gene/58331/otud5-(otu-deubiquitinase-5)