USP49 (ubiquitin specific peptidase 49)

2021-06-01  

Identity

HGNC
LOCATION
6p21.1
LOCUSID
ALIAS
-

Other Information

Locus ID:

NCBI: 25862
HGNC: 20078
Ensembl: ENSG00000164663

Variants:

dbSNP: 25862
ClinVar: 25862
TCGA: ENSG00000164663
COSMIC: USP49

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000164663ENST00000373006Q70CQ1
ENSG00000164663ENST00000373010Q5T3E1
ENSG00000164663ENST00000394253Q70CQ1
ENSG00000164663ENST00000423567A6PVU3
ENSG00000164663ENST00000448078H7BZI7

Expression (GTEx)

0
5
10
15

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
DeubiquitinationREACTOMER-HSA-5688426
Ub-specific processing proteasesREACTOMER-HSA-5689880

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
350725152022USP49-Mediated Histone H2B Deubiquitination Regulates HCT116 Cell Proliferation through MDM2-p53 Axis.1
352733622022Genome-wide screening for deubiquitinase subfamily identifies ubiquitin-specific protease 49 as a novel regulator of odontogenesis.3
353184412022USP49 mediates tumor progression and poor prognosis through a YAP1-dependent feedback loop in gastric cancer.7
353678232022c-MYC-USP49-BAG2 axis promotes proliferation and chemoresistance of colorectal cancer cells in vitro.8
355986812022USP49 is a novel deubiquitylating enzyme for γ H2AX in DNA double-strand break repair.1
350725152022USP49-Mediated Histone H2B Deubiquitination Regulates HCT116 Cell Proliferation through MDM2-p53 Axis.1
352733622022Genome-wide screening for deubiquitinase subfamily identifies ubiquitin-specific protease 49 as a novel regulator of odontogenesis.3
353184412022USP49 mediates tumor progression and poor prognosis through a YAP1-dependent feedback loop in gastric cancer.7
353678232022c-MYC-USP49-BAG2 axis promotes proliferation and chemoresistance of colorectal cancer cells in vitro.8
355986812022USP49 is a novel deubiquitylating enzyme for γ H2AX in DNA double-strand break repair.1
326919512020The long non-coding RNA HLNC1 potentiates hepatocellular carcinoma progression via interaction with USP49.7
327377722020Ubiquitin-specific protease 49 attenuates IL-1β-induced rat primary chondrocyte apoptosis by facilitating Axin deubiquitination and subsequent Wnt/β-catenin signaling cascade inhibition.6
326919512020The long non-coding RNA HLNC1 potentiates hepatocellular carcinoma progression via interaction with USP49.7
327377722020Ubiquitin-specific protease 49 attenuates IL-1β-induced rat primary chondrocyte apoptosis by facilitating Axin deubiquitination and subsequent Wnt/β-catenin signaling cascade inhibition.6
302464572019USP49 inhibits ischemia-reperfusion-induced cell viability suppression and apoptosis in human AC16 cardiomyocytes through DUSP1-JNK1/2 signaling.13

Citation

Dessen P

USP49 (ubiquitin specific peptidase 49)

Atlas Genet Cytogenet Oncol Haematol. 2021-06-01

Online version: http://atlasgeneticsoncology.org/gene/58369/usp49-(ubiquitin-specific-peptidase-49)