PARP4 (poly(ADP-ribose) polymerase family member 4)

2003-12-01  

Identity

HGNC
PARP4
LOCATION
13q12.12
LOCUSID
143
ALIAS
ADPRTL1,ARTD4,PARP-4,PARPL,PH5P,VAULT3,VPARP,VWA5C,p193
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 143
MIM: 607519
HGNC: 271
Ensembl: ENSG00000102699

Variants:

dbSNP: 143
ClinVar: 143
TCGA: ENSG00000102699
COSMIC: PARP4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000102699ENST00000381989Q9UKK3

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Base excision repairKEGGko03410
ApoptosisKEGGko04210
Base excision repairKEGGhsa03410
ApoptosisKEGGhsa04210
BER complexKEGGhsa_M00296
BER complexKEGGM00296
MetabolismREACTOMER-HSA-1430728
Metabolism of vitamins and cofactorsREACTOMER-HSA-196854
Metabolism of water-soluble vitamins and cofactorsREACTOMER-HSA-196849
Nicotinate metabolismREACTOMER-HSA-196807
Nicotinamide salvagingREACTOMER-HSA-197264

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
390344022024PARP4 interacts with hnRNPM to regulate splicing during lung cancer progression.1
390344022024PARP4 interacts with hnRNPM to regulate splicing during lung cancer progression.1
370133462023Identification of a novel PARP4 gene promoter CpG locus associated with cisplatin chemoresistance.0
379713102023Structural and biochemical analysis of the PARP1-homology region of PARP4/vault PARP.1
370133462023Identification of a novel PARP4 gene promoter CpG locus associated with cisplatin chemoresistance.0
379713102023Structural and biochemical analysis of the PARP1-homology region of PARP4/vault PARP.1
356277772022Modification Effect of PARP4 and ERCC1 Gene Polymorphisms on the Relationship between Particulate Matter Exposure and Fasting Glucose Level.2
356277772022Modification Effect of PARP4 and ERCC1 Gene Polymorphisms on the Relationship between Particulate Matter Exposure and Fasting Glucose Level.2
348299992021MVP Expression Facilitates Tumor Cell Proliferation and Migration Supporting the Metastasis of Colorectal Cancer Cells.4
348299992021MVP Expression Facilitates Tumor Cell Proliferation and Migration Supporting the Metastasis of Colorectal Cancer Cells.4
323166962020Modification of PARP4, XRCC3, and RAD51 Gene Polymorphisms on the Relation between Bisphenol A Exposure and Liver Abnormality.3
323166962020Modification of PARP4, XRCC3, and RAD51 Gene Polymorphisms on the Relation between Bisphenol A Exposure and Liver Abnormality.3
310023692019Single‑cell intratumoral stemness analysis reveals the involvement of cell cycle and DNA damage repair in two different types of esophageal cancer.10
311195702019Assessment of PARP4 as a candidate breast cancer susceptibility gene.8
312031372019Genetic variants of PARP4 gene and PARP4P2 pseudogene in patients with multiple primary tumors including thyroid cancer.5

Citation

Dessen P

PARP4 (poly(ADP-ribose) polymerase family member 4)

Atlas Genet Cytogenet Oncol Haematol. 2003-12-01

Online version: http://atlasgeneticsoncology.org/gene/587/parp4-(poly(adp-ribose)-polymerase-family-member-4)