GRK2 (G protein-coupled receptor kinase 2)

2003-11-01 Affiliation

Identity

HGNC

GRK2

LOCATION

11q13.2

LOCUSID

156

ALIAS

ADRBK1,BARK1,BETA-ARK1

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 156
MIM: 109635
HGNC: 289
Ensembl: ENSG00000173020

Variants:

dbSNP: 156
ClinVar: 156
TCGA: ENSG00000173020
COSMIC: GRK2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000173020	ENST00000308595	P25098
ENSG00000173020	ENST00000308595	A0A0S2Z392
ENSG00000173020	ENST00000526285	E9PRV7

Expression (GTEx)

100

150

200

250

300

350

400

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Hedgehog signaling pathway	KEGG	ko04340
Olfactory transduction	KEGG	ko04740
Hedgehog signaling pathway	KEGG	hsa04340
Olfactory transduction	KEGG	hsa04740
Chemokine signaling pathway	KEGG	ko04062
Chemokine signaling pathway	KEGG	hsa04062
Endocytosis	KEGG	ko04144
Endocytosis	KEGG	hsa04144
Glutamatergic synapse	KEGG	ko04724
Glutamatergic synapse	KEGG	hsa04724
Morphine addiction	KEGG	hsa05032
Morphine addiction	KEGG	ko05032
Immune System	REACTOME	R-HSA-168256
Innate Immune System	REACTOME	R-HSA-168249
DAP12 interactions	REACTOME	R-HSA-2172127
DAP12 signaling	REACTOME	R-HSA-2424491
DAG and IP3 signaling	REACTOME	R-HSA-1489509
CaM pathway	REACTOME	R-HSA-111997
Calmodulin induced events	REACTOME	R-HSA-111933
Signal Transduction	REACTOME	R-HSA-162582
Signaling by EGFR	REACTOME	R-HSA-177929
EGFR interacts with phospholipase C-gamma	REACTOME	R-HSA-212718
Signalling by NGF	REACTOME	R-HSA-166520
NGF signalling via TRKA from the plasma membrane	REACTOME	R-HSA-187037
PLC-gamma1 signalling	REACTOME	R-HSA-167021
Signaling by PDGF	REACTOME	R-HSA-186797
Downstream signal transduction	REACTOME	R-HSA-186763
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR downstream signaling	REACTOME	R-HSA-388396
G alpha (s) signalling events	REACTOME	R-HSA-418555
G alpha (q) signalling events	REACTOME	R-HSA-416476
Opioid Signalling	REACTOME	R-HSA-111885
G-protein mediated events	REACTOME	R-HSA-112040
PLC beta mediated events	REACTOME	R-HSA-112043
Ca-dependent events	REACTOME	R-HSA-111996
Gastrin-CREB signalling pathway via PKC and MAPK	REACTOME	R-HSA-881907
Signaling by Hedgehog	REACTOME	R-HSA-5358351
Hedgehog 'on' state	REACTOME	R-HSA-5632684
Activation of SMO	REACTOME	R-HSA-5635838
Vesicle-mediated transport	REACTOME	R-HSA-5653656
Membrane Trafficking	REACTOME	R-HSA-199991
Clathrin-mediated endocytosis	REACTOME	R-HSA-8856828
Cargo recognition for clathrin-mediated endocytosis	REACTOME	R-HSA-8856825

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PMIDs
PA30616	MAPK1	Gene	Pathway	associated
PA320	SLC12A1	Gene	Pathway	associated	23788015
PA39	ADRB2	Gene	Pathway	associated
PA62	ATP1A1	Gene	Pathway	associated	23788015

References

Pubmed ID	Year	Title	Citations
38242702	2024	GRK2-YAP signaling is implicated in pulmonary arterial hypertension development.	0
38446273	2024	Exploring the potential biological function of GRK2 in colorectal cancer.	0
38242702	2024	GRK2-YAP signaling is implicated in pulmonary arterial hypertension development.	0
38446273	2024	Exploring the potential biological function of GRK2 in colorectal cancer.	0
36622065	2023	Gender differences in GRK2 in cardiovascular diseases and its interactions with estrogen.	2
36801996	2023	CXCL9, 10, 11/CXCR3 Axis Contributes to the Progress of Primary Sjogren's Syndrome by Activating GRK2 to Promote T Lymphocyte Migration.	2
37892234	2023	G Protein-Coupled Receptor Kinase 2 Selectively Enhances β-Arrestin Recruitment to the D(2) Dopamine Receptor through Mechanisms That Are Independent of Receptor Phosphorylation.	0
36622065	2023	Gender differences in GRK2 in cardiovascular diseases and its interactions with estrogen.	2
36801996	2023	CXCL9, 10, 11/CXCR3 Axis Contributes to the Progress of Primary Sjogren's Syndrome by Activating GRK2 to Promote T Lymphocyte Migration.	2
37892234	2023	G Protein-Coupled Receptor Kinase 2 Selectively Enhances β-Arrestin Recruitment to the D(2) Dopamine Receptor through Mechanisms That Are Independent of Receptor Phosphorylation.	0
35341806	2022	GRK2 selectively attenuates the neutrophil NADPH-oxidase response triggered by β-arrestin recruiting GPR84 agonists.	1
35878706	2022	GRK2 in cardiovascular disease and its potential as a therapeutic target.	3
36063601	2022	The tyrosine phosphorylation of GRK2 is responsible for activated D(2)R-mediated insulin resistance.	0
36461590	2022	Targeted inhibition of the GRK2/HIF-1α pathway is an effective strategy to alleviate synovial hypoxia and inflammation.	2
35341806	2022	GRK2 selectively attenuates the neutrophil NADPH-oxidase response triggered by β-arrestin recruiting GPR84 agonists.	1

Citation

Dessen P

GRK2 (G protein-coupled receptor kinase 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/590/grk2-(g-protein-coupled-receptor-kinase-2)