GRK2 (G protein-coupled receptor kinase 2)

2003-11-01  

Identity

HGNC
LOCATION
11q13.2
LOCUSID
ALIAS
ADRBK1,BARK1,BETA-ARK1
FUSION GENES

Other Information

Locus ID:

NCBI: 156
MIM: 109635
HGNC: 289
Ensembl: ENSG00000173020

Variants:

dbSNP: 156
ClinVar: 156
TCGA: ENSG00000173020
COSMIC: GRK2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000173020ENST00000308595P25098
ENSG00000173020ENST00000308595A0A0S2Z392
ENSG00000173020ENST00000526285E9PRV7

Expression (GTEx)

0
50
100
150
200
250
300
350
400

Pathways

PathwaySourceExternal ID
Hedgehog signaling pathwayKEGGko04340
Olfactory transductionKEGGko04740
Hedgehog signaling pathwayKEGGhsa04340
Olfactory transductionKEGGhsa04740
Chemokine signaling pathwayKEGGko04062
Chemokine signaling pathwayKEGGhsa04062
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144
Glutamatergic synapseKEGGko04724
Glutamatergic synapseKEGGhsa04724
Morphine addictionKEGGhsa05032
Morphine addictionKEGGko05032
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
DAP12 interactionsREACTOMER-HSA-2172127
DAP12 signalingREACTOMER-HSA-2424491
DAG and IP3 signalingREACTOMER-HSA-1489509
CaM pathwayREACTOMER-HSA-111997
Calmodulin induced eventsREACTOMER-HSA-111933
Signal TransductionREACTOMER-HSA-162582
Signaling by EGFRREACTOMER-HSA-177929
EGFR interacts with phospholipase C-gammaREACTOMER-HSA-212718
Signalling by NGFREACTOMER-HSA-166520
NGF signalling via TRKA from the plasma membraneREACTOMER-HSA-187037
PLC-gamma1 signallingREACTOMER-HSA-167021
Signaling by PDGFREACTOMER-HSA-186797
Downstream signal transductionREACTOMER-HSA-186763
Signaling by GPCRREACTOMER-HSA-372790
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (s) signalling eventsREACTOMER-HSA-418555
G alpha (q) signalling eventsREACTOMER-HSA-416476
Opioid SignallingREACTOMER-HSA-111885
G-protein mediated eventsREACTOMER-HSA-112040
PLC beta mediated eventsREACTOMER-HSA-112043
Ca-dependent eventsREACTOMER-HSA-111996
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907
Signaling by HedgehogREACTOMER-HSA-5358351
Hedgehog 'on' stateREACTOMER-HSA-5632684
Activation of SMOREACTOMER-HSA-5635838
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Clathrin-mediated endocytosisREACTOMER-HSA-8856828
Cargo recognition for clathrin-mediated endocytosisREACTOMER-HSA-8856825

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA30616MAPK1GenePathwayassociated
PA320SLC12A1GenePathwayassociated23788015
PA39ADRB2GenePathwayassociated
PA62ATP1A1GenePathwayassociated23788015

References

Pubmed IDYearTitleCitations
174825452007Regulation of beta-adrenergic receptor signaling by S-nitrosylation of G-protein-coupled receptor kinase 2.141
184251302008A GRK5 polymorphism that inhibits beta-adrenergic receptor signaling is protective in heart failure.118
156185192004Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2.98
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
158434352005G protein-coupled receptor kinase 2-mediated phosphorylation of ezrin is required for G protein-coupled receptor-dependent reorganization of the actin cytoskeleton.63
234678202013Prodeath signaling of G protein-coupled receptor kinase 2 in cardiac myocytes after ischemic stress occurs via extracellular signal-regulated kinase-dependent heat shock protein 90-mediated mitochondrial targeting.60
208140222010Level of G protein-coupled receptor kinase-2 determines myocardial ischemia/reperfusion injury via pro- and anti-apoptotic mechanisms.59
227313842012MicroRNA-124 as a novel treatment for persistent hyperalgesia.53
170065432006Mdm2 is involved in the ubiquitination and degradation of G-protein-coupled receptor kinase 2.49
168496372006Impaired neutrophil chemotaxis in sepsis associates with GRK expression and inhibition of actin assembly and tyrosine phosphorylation.48

Citation

Dessen P

GRK2 (G protein-coupled receptor kinase 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/590/grk2-(g-protein-coupled-receptor-kinase-2)