Identity
HGNC
LOCATION
11q13.2
LOCUSID
ALIAS
ADRBK1,BARK1,BETA-ARK1
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 156
MIM: 109635
HGNC: 289
Ensembl: ENSG00000173020
Variants:
dbSNP: 156
ClinVar: 156
TCGA: ENSG00000173020
COSMIC: GRK2
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000173020 | ENST00000308595 | P25098 |
| ENSG00000173020 | ENST00000308595 | A0A0S2Z392 |
| ENSG00000173020 | ENST00000526285 | E9PRV7 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA30616 | MAPK1 | Gene | Pathway | associated | |||
| PA320 | SLC12A1 | Gene | Pathway | associated | 23788015 | ||
| PA39 | ADRB2 | Gene | Pathway | associated | |||
| PA62 | ATP1A1 | Gene | Pathway | associated | 23788015 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38242702 | 2024 | GRK2-YAP signaling is implicated in pulmonary arterial hypertension development. | 0 |
| 38446273 | 2024 | Exploring the potential biological function of GRK2 in colorectal cancer. | 0 |
| 38242702 | 2024 | GRK2-YAP signaling is implicated in pulmonary arterial hypertension development. | 0 |
| 38446273 | 2024 | Exploring the potential biological function of GRK2 in colorectal cancer. | 0 |
| 36622065 | 2023 | Gender differences in GRK2 in cardiovascular diseases and its interactions with estrogen. | 2 |
| 36801996 | 2023 | CXCL9, 10, 11/CXCR3 Axis Contributes to the Progress of Primary Sjogren's Syndrome by Activating GRK2 to Promote T Lymphocyte Migration. | 2 |
| 37892234 | 2023 | G Protein-Coupled Receptor Kinase 2 Selectively Enhances β-Arrestin Recruitment to the D(2) Dopamine Receptor through Mechanisms That Are Independent of Receptor Phosphorylation. | 0 |
| 36622065 | 2023 | Gender differences in GRK2 in cardiovascular diseases and its interactions with estrogen. | 2 |
| 36801996 | 2023 | CXCL9, 10, 11/CXCR3 Axis Contributes to the Progress of Primary Sjogren's Syndrome by Activating GRK2 to Promote T Lymphocyte Migration. | 2 |
| 37892234 | 2023 | G Protein-Coupled Receptor Kinase 2 Selectively Enhances β-Arrestin Recruitment to the D(2) Dopamine Receptor through Mechanisms That Are Independent of Receptor Phosphorylation. | 0 |
| 35341806 | 2022 | GRK2 selectively attenuates the neutrophil NADPH-oxidase response triggered by β-arrestin recruiting GPR84 agonists. | 1 |
| 35878706 | 2022 | GRK2 in cardiovascular disease and its potential as a therapeutic target. | 3 |
| 36063601 | 2022 | The tyrosine phosphorylation of GRK2 is responsible for activated D(2)R-mediated insulin resistance. | 0 |
| 36461590 | 2022 | Targeted inhibition of the GRK2/HIF-1α pathway is an effective strategy to alleviate synovial hypoxia and inflammation. | 2 |
| 35341806 | 2022 | GRK2 selectively attenuates the neutrophil NADPH-oxidase response triggered by β-arrestin recruiting GPR84 agonists. | 1 |
Citation
Dessen P
GRK2 (G protein-coupled receptor kinase 2)
Atlas Genet Cytogenet Oncol Haematol. 2003-11-01
Online version: http://atlasgeneticsoncology.org/gene/590/grk2-(g-protein-coupled-receptor-kinase-2)
