AHR (aryl hydrocarbon receptor)

2003-08-01  

Identity

HGNC
AHR
LOCATION
7p21.1
LOCUSID
196
ALIAS
RP85,bHLHe76
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 196
MIM: 600253
HGNC: 348
Ensembl: ENSG00000106546

Variants:

dbSNP: 196
ClinVar: 196
TCGA: ENSG00000106546
COSMIC: AHR

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000106546ENST00000242057P35869
ENSG00000106546ENST00000242057A0A024R9Z8
ENSG00000106546ENST00000463496P35869
ENSG00000106546ENST00000463496A0A024R9Z8
ENSG00000106546ENST00000642825A0A2R8Y7G1

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolismREACTOMER-HSA-535734
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)REACTOMER-HSA-400206
PPARA activates gene expressionREACTOMER-HSA-1989781
Biological oxidationsREACTOMER-HSA-211859
Phase 1 - Functionalization of compoundsREACTOMER-HSA-211945
Cytochrome P450 - arranged by substrate typeREACTOMER-HSA-211897
Endogenous sterolsREACTOMER-HSA-211976
XenobioticsREACTOMER-HSA-211981
Th17 cell differentiationKEGGko04659
Th17 cell differentiationKEGGhsa04659
Aryl hydrocarbon receptor signallingREACTOMER-HSA-8937144

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA165816878methylcholanthreneChemicalVipGeneassociated17481570
PA166157322rs2066853VariantVipGeneassociated11207035, 11505220, 11866883, 12852830, 15860653, 7550366, 10739168
PA447215Psychotic DisordersDiseaseClinicalAnnotationassociatedPK23492908
PA450688olanzapineChemicalClinicalAnnotationassociatedPK23492908
PA450704omeprazoleChemicalVariantAnnotationassociatedPK15860653
PA452604xenobioticsChemicalVariantAnnotationambiguousPK11207035, 15860653

References

Pubmed IDYearTitleCitations
380360132024Regulation of long non-coding RNA expression by aryl hydrocarbon receptor activation.0
381425332024Silencing of aryl hydrocarbon receptor repressor restrains Th17 cell immunity in autoimmune hepatitis.0
382200082024Pyrene and its derivatives increase lung adverse effects by activating aryl hydrocarbon receptor transcription.0
382382532024Aryl hydrocarbon receptor: Linking environment to aging process in elderly patients with asthma.1
383161812024Proteomic insight towards key modulating proteins regulated by the aryl hydrocarbon receptor involved in ovarian carcinogenesis and chemoresistance.1
383619442024The role of aryl hydrocarbon receptor in vitiligo: a review.0
384041792024AHR signaling pathway mediates mitochondrial oxidative phosphorylation which leads to cytarabine resistance.0
384085872024hsa_circ_0008500 regulates Benzo(a)pyrene-loaded gypsum-induced inflammation and apoptosis in human bronchial epithelial cells via activation of Ahr/C-myc pathways.0
384590882024Aryl hydrocarbon receptor suppresses STING-mediated type I IFN expression in triple-negative breast cancer.1
385092642024A microbially produced AhR ligand promotes a Tph1-driven tolerogenic program in multiple sclerosis.1
385189962024Targeting aryl hydrocarbon receptor to prevent cancer in barrier organs.1
386036302024Mechanisms underlying aryl hydrocarbon receptor-driven divergent macrophage function.1
386152652024Association between estrogen receptor alpha and aryl hydrocarbon receptor gene polymorphisms in the prognosis of breast cancer in Egypt.0
386804962024Exploring aryl hydrocarbon receptor expression and distribution in the tumor microenvironment, with a focus on immune cells, in various solid cancer types.0
389875862024Interferon subverts an AHR-JUN axis to promote CXCL13(+) T cells in lupus.0

Citation

Dessen P

AHR (aryl hydrocarbon receptor)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/598/ahr-(aryl-hydrocarbon-receptor)