ACAD9 (acyl-CoA dehydrogenase family member 9)

2014-11-01  

Identity

HGNC
LOCATION
3q21.3
LOCUSID
ALIAS
MC1DN20,NPD002
FUSION GENES

Other Information

Locus ID:

NCBI: 28976
MIM: 611103
HGNC: 21497
Ensembl: ENSG00000177646

Variants:

dbSNP: 28976
ClinVar: 28976
TCGA: ENSG00000177646
COSMIC: ACAD9

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000177646ENST00000308982Q9H845
ENSG00000177646ENST00000505192D6RGK6
ENSG00000177646ENST00000505867D6RDK9
ENSG00000177646ENST00000508971H0Y8Z9
ENSG00000177646ENST00000511227D6RDK9
ENSG00000177646ENST00000512801D6RJA8
ENSG00000177646ENST00000514336D6RCD8
ENSG00000177646ENST00000514643D6R9Z3
ENSG00000177646ENST00000515429D6RDK9

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
The citric acid (TCA) cycle and respiratory electron transportREACTOMER-HSA-1428517
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.REACTOMER-HSA-163200
Respiratory electron transportREACTOMER-HSA-611105
Complex I biogenesisREACTOMER-HSA-6799198

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
373887272023Immunodeficiency with susceptibility to lymphoma with complex genotype affecting energy metabolism (FBP1, ACAD9) and vesicle trafficking (RAB27A).0
373887272023Immunodeficiency with susceptibility to lymphoma with complex genotype affecting energy metabolism (FBP1, ACAD9) and vesicle trafficking (RAB27A).0
293486072018Evaluation of mitochondrial bioenergetics, dynamics, endoplasmic reticulum-mitochondria crosstalk, and reactive oxygen species in fibroblasts from patients with complex I deficiency.28
293486072018Evaluation of mitochondrial bioenergetics, dynamics, endoplasmic reticulum-mitochondria crosstalk, and reactive oxygen species in fibroblasts from patients with complex I deficiency.28
266696602016High incidence and variable clinical outcome of cardiac hypertrophy due to ACAD9 mutations in childhood.12
268264062016Neonatal multiorgan failure due to ACAD9 mutation and complex I deficiency with mitochondrial hyperplasia in liver, cardiac myocytes, skeletal muscle, and renal tubules.13
272332272016Evidence of a wide spectrum of cardiac involvement due to ACAD9 mutations: Report on nine patients.10
266696602016High incidence and variable clinical outcome of cardiac hypertrophy due to ACAD9 mutations in childhood.12
268264062016Neonatal multiorgan failure due to ACAD9 mutation and complex I deficiency with mitochondrial hyperplasia in liver, cardiac myocytes, skeletal muscle, and renal tubules.13
272332272016Evidence of a wide spectrum of cardiac involvement due to ACAD9 mutations: Report on nine patients.10
257214012015Complex I assembly function and fatty acid oxidation enzyme activity of ACAD9 both contribute to disease severity in ACAD9 deficiency.24
257214012015Complex I assembly function and fatty acid oxidation enzyme activity of ACAD9 both contribute to disease severity in ACAD9 deficiency.24
241588522014ACAD9, a complex I assembly factor with a moonlighting function in fatty acid oxidation deficiencies.22
241588522014ACAD9, a complex I assembly factor with a moonlighting function in fatty acid oxidation deficiencies.22
222779672012Molecular diagnosis of infantile mitochondrial disease with targeted next-generation sequencing.201

Citation

Dessen P

ACAD9 (acyl-CoA dehydrogenase family member 9)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/60071/acad9-(acyl-coa-dehydrogenase-family-member-9)