ACOX1 (acyl-CoA oxidase 1)

2014-11-01  

Identity

HGNC
ACOX1
LOCATION
17q25.1
LOCUSID
51
ALIAS
ACOX,MITCH,PALMCOX,SCOX
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 51
MIM: 609751
HGNC: 119
Ensembl: ENSG00000161533

Variants:

dbSNP: 51
ClinVar: 51
TCGA: ENSG00000161533
COSMIC: ACOX1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000161533ENST00000293217Q15067
ENSG00000161533ENST00000301608Q15067
ENSG00000161533ENST00000572047I3L2U4
ENSG00000161533ENST00000573078I3L0T4
ENSG00000161533ENST00000576743I3L4S5
ENSG00000161533ENST00000587927K7ENF1
ENSG00000161533ENST00000588176K7ELT1
ENSG00000161533ENST00000588968K7ESC7
ENSG00000161533ENST00000589301I3L2U4

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Fatty acid degradationKEGGko00071
alpha-Linolenic acid metabolismKEGGko00592
Biosynthesis of unsaturated fatty acidsKEGGko01040
PPAR signaling pathwayKEGGko03320
Fatty acid degradationKEGGhsa00071
alpha-Linolenic acid metabolismKEGGhsa00592
Biosynthesis of unsaturated fatty acidsKEGGhsa01040
PPAR signaling pathwayKEGGhsa03320
PeroxisomeKEGGko04146
PeroxisomeKEGGhsa04146
Metabolic pathwaysKEGGhsa01100
beta-OxidationKEGGhsa_M00087
beta-OxidationKEGGM00087
Fatty acid metabolismKEGGhsa01212
Fatty acid metabolismKEGGko01212
cAMP signaling pathwayKEGGhsa04024
cAMP signaling pathwayKEGGko04024
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolismREACTOMER-HSA-535734
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)REACTOMER-HSA-400206
PPARA activates gene expressionREACTOMER-HSA-1989781
Peroxisomal lipid metabolismREACTOMER-HSA-390918
Beta-oxidation of very long chain fatty acidsREACTOMER-HSA-390247
alpha-linolenic (omega3) and linoleic (omega6) acid metabolismREACTOMER-HSA-2046104
alpha-linolenic acid (ALA) metabolismREACTOMER-HSA-2046106

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
186604892008Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations.26
174588722007Clinical, biochemical, and mutational spectrum of peroxisomal acyl-coenzyme A oxidase deficiency.25
201952422010Reversal of mouse Acyl-CoA oxidase 1 (ACOX1) null phenotype by human ACOX1b isoform [corrected].19
244180042014Very-long-chain polyunsaturated fatty acids accumulate in phosphatidylcholine of fibroblasts from patients with Zellweger syndrome and acyl-CoA oxidase1 deficiency.17
185360482008Peroxisomal acyl-CoA-oxidase deficiency: two new cases.4
239332002013Altered phospholipid molecular species and glycolipid composition in brain, liver and fibroblasts of Zellweger syndrome.1
311268022019miR-222 targets ACOX1, promotes triglyceride accumulation in hepatocytes.0

Citation

Dessen P

ACOX1 (acyl-CoA oxidase 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/60093/acox1-(acyl-coa-oxidase-1)