Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 49
MIM: 102480
HGNC: 126
Ensembl: ENSG00000100312
Variants:
dbSNP: 49
ClinVar: 49
TCGA: ENSG00000100312
COSMIC: ACR
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000100312 | ENST00000216139 | P10323 |
| ENSG00000100312 | ENST00000529621 | E9PLV5 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Reproduction | REACTOME | R-HSA-1474165 |
| Fertilization | REACTOME | R-HSA-1187000 |
| Acrosome Reaction | REACTOME | R-HSA-1300645 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37833433 | 2023 | Low acrosin activity is associated with decreased Spam1/acrosin expression and GSH deficiency-caused premature acrosome release of human sperm cells. | 1 |
| 37833433 | 2023 | Low acrosin activity is associated with decreased Spam1/acrosin expression and GSH deficiency-caused premature acrosome release of human sperm cells. | 1 |
| 30428044 | 2019 | Mitochondrial functionality modifies human sperm acrosin activity, acrosome reaction capability and chromatin integrity. | 29 |
| 30428044 | 2019 | Mitochondrial functionality modifies human sperm acrosin activity, acrosome reaction capability and chromatin integrity. | 29 |
| 23675907 | 2013 | Expression analysis of MND1/GAJ, SPATA22, GAPDHS and ACR genes in testicular biopsies from non-obstructive azoospermia (NOA) patients. | 10 |
| 23675907 | 2013 | Expression analysis of MND1/GAJ, SPATA22, GAPDHS and ACR genes in testicular biopsies from non-obstructive azoospermia (NOA) patients. | 10 |
| 22452365 | 2012 | DNA immunization against proacrosin impairs fertility in male mice. | 1 |
| 23297503 | 2012 | [Sperm DNA damage and sperm-nucleoprotein transition correlate to acrosin activity and seminal parameters]. | 0 |
| 22452365 | 2012 | DNA immunization against proacrosin impairs fertility in male mice. | 1 |
| 23297503 | 2012 | [Sperm DNA damage and sperm-nucleoprotein transition correlate to acrosin activity and seminal parameters]. | 0 |
| 15950651 | 2005 | Binding of recombinant human proacrosin/acrosin to zona pellucida (ZP) glycoproteins. I. Studies with recombinant human ZPA, ZPB, and ZPC. | 5 |
| 15950651 | 2005 | Binding of recombinant human proacrosin/acrosin to zona pellucida (ZP) glycoproteins. I. Studies with recombinant human ZPA, ZPB, and ZPC. | 5 |
Citation
Dessen P
ACR (acrosin)
Atlas Genet Cytogenet Oncol Haematol. 2014-11-01
Online version: http://atlasgeneticsoncology.org/gene/60097/acr-(acrosin)
