ADCY3 (adenylate cyclase 3)

2014-11-01 Affiliation

Identity

HGNC

ADCY3

LOCATION

2p23.3

LOCUSID

109

ALIAS

AC-III,AC3,BMIQ19

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 109
MIM: 600291
HGNC: 234
Ensembl: ENSG00000138031

Variants:

dbSNP: 109
ClinVar: 109
TCGA: ENSG00000138031
COSMIC: ADCY3

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000138031	ENST00000260600	O60266
ENSG00000138031	ENST00000405392	A0A0A0MSC1
ENSG00000138031	ENST00000427849	H7C1A6
ENSG00000138031	ENST00000433852	C9JYB5
ENSG00000138031	ENST00000435135	C9JLX3
ENSG00000138031	ENST00000438445	C9J969
ENSG00000138031	ENST00000455323	H7C1S5
ENSG00000138031	ENST00000498288	U3KQR1
ENSG00000138031	ENST00000606682	U3KQ91

Expression (GTEx)

100

150

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Purine metabolism	KEGG	ko00230
Calcium signaling pathway	KEGG	ko04020
Gap junction	KEGG	ko04540
Olfactory transduction	KEGG	ko04740
GnRH signaling pathway	KEGG	ko04912
Progesterone-mediated oocyte maturation	KEGG	ko04914
Melanogenesis	KEGG	ko04916
Vibrio cholerae infection	KEGG	ko05110
Purine metabolism	KEGG	hsa00230
Calcium signaling pathway	KEGG	hsa04020
Gap junction	KEGG	hsa04540
Olfactory transduction	KEGG	hsa04740
GnRH signaling pathway	KEGG	hsa04912
Melanogenesis	KEGG	hsa04916
Vibrio cholerae infection	KEGG	hsa05110
Pathways in cancer	KEGG	hsa05200
Vascular smooth muscle contraction	KEGG	hsa04270
Chemokine signaling pathway	KEGG	ko04062
Vascular smooth muscle contraction	KEGG	ko04270
Chemokine signaling pathway	KEGG	hsa04062
Progesterone-mediated oocyte maturation	KEGG	hsa04914
Dilated cardiomyopathy	KEGG	ko05414
Dilated cardiomyopathy	KEGG	hsa05414
Oocyte meiosis	KEGG	ko04114
Oocyte meiosis	KEGG	hsa04114
Vasopressin-regulated water reabsorption	KEGG	ko04962
Vasopressin-regulated water reabsorption	KEGG	hsa04962
Salivary secretion	KEGG	ko04970
Salivary secretion	KEGG	hsa04970
Gastric acid secretion	KEGG	ko04971
Gastric acid secretion	KEGG	hsa04971
Pancreatic secretion	KEGG	ko04972
Pancreatic secretion	KEGG	hsa04972
Bile secretion	KEGG	ko04976
Bile secretion	KEGG	hsa04976
Glutamatergic synapse	KEGG	ko04724
Glutamatergic synapse	KEGG	hsa04724
Cholinergic synapse	KEGG	hsa04725
HTLV-I infection	KEGG	ko05166
HTLV-I infection	KEGG	hsa05166
GABAergic synapse	KEGG	ko04727
GABAergic synapse	KEGG	hsa04727
Retrograde endocannabinoid signaling	KEGG	hsa04723
Retrograde endocannabinoid signaling	KEGG	ko04723
Morphine addiction	KEGG	hsa05032
Morphine addiction	KEGG	ko05032
Circadian entrainment	KEGG	hsa04713
Circadian entrainment	KEGG	ko04713
Insulin secretion	KEGG	hsa04911
Ovarian steroidogenesis	KEGG	hsa04913
Ovarian steroidogenesis	KEGG	ko04913
Estrogen signaling pathway	KEGG	hsa04915
Estrogen signaling pathway	KEGG	ko04915
Thyroid hormone synthesis	KEGG	hsa04918
Thyroid hormone synthesis	KEGG	ko04918
Rap1 signaling pathway	KEGG	hsa04015
Rap1 signaling pathway	KEGG	ko04015
Adrenergic signaling in cardiomyocytes	KEGG	hsa04261
Adrenergic signaling in cardiomyocytes	KEGG	ko04261
Inflammatory mediator regulation of TRP channels	KEGG	hsa04750
Inflammatory mediator regulation of TRP channels	KEGG	ko04750
Platelet activation	KEGG	hsa04611
Oxytocin signaling pathway	KEGG	hsa04921
Oxytocin signaling pathway	KEGG	ko04921
cGMP-PKG signaling pathway	KEGG	hsa04022
cGMP-PKG signaling pathway	KEGG	ko04022
cAMP signaling pathway	KEGG	hsa04024
cAMP signaling pathway	KEGG	ko04024
cAMP signaling	KEGG	hsa_M00695
cAMP signaling	KEGG	M00695
Regulation of lipolysis in adipocytes	KEGG	hsa04923
Neuronal System	REACTOME	R-HSA-112316
Transmission across Chemical Synapses	REACTOME	R-HSA-112315
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell	REACTOME	R-HSA-112314
Activation of NMDA receptor upon glutamate binding and postsynaptic events	REACTOME	R-HSA-442755
Post NMDA receptor activation events	REACTOME	R-HSA-438064
CREB phosphorylation through the activation of Adenylate Cyclase	REACTOME	R-HSA-442720
GABA receptor activation	REACTOME	R-HSA-977443
GABA B receptor activation	REACTOME	R-HSA-977444
Activation of GABAB receptors	REACTOME	R-HSA-991365
Inhibition of adenylate cyclase pathway	REACTOME	R-HSA-997269
Adenylate cyclase inhibitory pathway	REACTOME	R-HSA-170670
Immune System	REACTOME	R-HSA-168256
Innate Immune System	REACTOME	R-HSA-168249
DAP12 interactions	REACTOME	R-HSA-2172127
DAP12 signaling	REACTOME	R-HSA-2424491
DAG and IP3 signaling	REACTOME	R-HSA-1489509
CaM pathway	REACTOME	R-HSA-111997
Calmodulin induced events	REACTOME	R-HSA-111933
PKA-mediated phosphorylation of CREB	REACTOME	R-HSA-111931
PKA activation	REACTOME	R-HSA-163615
Signal Transduction	REACTOME	R-HSA-162582
Signaling by EGFR	REACTOME	R-HSA-177929
EGFR interacts with phospholipase C-gamma	REACTOME	R-HSA-212718
Signalling by NGF	REACTOME	R-HSA-166520
NGF signalling via TRKA from the plasma membrane	REACTOME	R-HSA-187037
PLC-gamma1 signalling	REACTOME	R-HSA-167021
Signaling by PDGF	REACTOME	R-HSA-186797
Downstream signal transduction	REACTOME	R-HSA-186763
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR downstream signaling	REACTOME	R-HSA-388396
G alpha (s) signalling events	REACTOME	R-HSA-418555
G alpha (i) signalling events	REACTOME	R-HSA-418594
G alpha (z) signalling events	REACTOME	R-HSA-418597
Opioid Signalling	REACTOME	R-HSA-111885
G-protein mediated events	REACTOME	R-HSA-112040
PLC beta mediated events	REACTOME	R-HSA-112043
Ca-dependent events	REACTOME	R-HSA-111996
Adenylate cyclase activating pathway	REACTOME	R-HSA-170660
Signaling by Hedgehog	REACTOME	R-HSA-5358351
Hedgehog 'off' state	REACTOME	R-HSA-5610787
Transmembrane transport of small molecules	REACTOME	R-HSA-382551
Aquaporin-mediated transport	REACTOME	R-HSA-445717
Vasopressin regulates renal water homeostasis via Aquaporins	REACTOME	R-HSA-432040
Metabolism	REACTOME	R-HSA-1430728
Integration of energy metabolism	REACTOME	R-HSA-163685
Glucagon signaling in metabolic regulation	REACTOME	R-HSA-163359
PKA activation in glucagon signalling	REACTOME	R-HSA-164378
Aldosterone synthesis and secretion	KEGG	hsa04925
Aldosterone synthesis and secretion	KEGG	ko04925
Phospholipase D signaling pathway	KEGG	ko04072
Phospholipase D signaling pathway	KEGG	hsa04072
Longevity regulating pathway	KEGG	hsa04211
Longevity regulating pathway - multiple species	KEGG	ko04213
Longevity regulating pathway - multiple species	KEGG	hsa04213
Endocrine resistance	KEGG	ko01522
Endocrine resistance	KEGG	hsa01522
Apelin signaling pathway	KEGG	hsa04371

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PMIDs
PA172	GNAI1	Gene	Pathway	associated	20938371
PA173	GNAI3	Gene	Pathway	associated	20938371
PA175	GNAS	Gene	Pathway	associated	20938371
PA176	GNB3	Gene	Pathway	associated	20938371
PA24347	GNAI2	Gene	Pathway	associated	20938371

References

Pubmed ID	Year	Title	Citations
37955134	2024	Adenylate cyclase 3: a potential genetic link between obesity and major depressive disorder.	1
38334651	2024	Postnatal Dynamic Ciliary ARL13B and ADCY3 Localization in the Mouse Brain.	0
38684889	2024	Cold-induced expression of a truncated adenylyl cyclase 3 acts as rheostat to brown fat function.	0
37955134	2024	Adenylate cyclase 3: a potential genetic link between obesity and major depressive disorder.	1
38334651	2024	Postnatal Dynamic Ciliary ARL13B and ADCY3 Localization in the Mouse Brain.	0
38684889	2024	Cold-induced expression of a truncated adenylyl cyclase 3 acts as rheostat to brown fat function.	0
34481002	2022	ALDH2, ADCY3 and BCMO1 polymorphisms and lifestyle-induced traits are jointly associated with CAD risk in Chinese Han people.	2
34821371	2022	Molecular modelling of novel ADCY3 variant predicts a molecular target for tackling obesity.	9
34481002	2022	ALDH2, ADCY3 and BCMO1 polymorphisms and lifestyle-induced traits are jointly associated with CAD risk in Chinese Han people.	2
34821371	2022	Molecular modelling of novel ADCY3 variant predicts a molecular target for tackling obesity.	9
29311635	2018	Subcellular localization of MC4R with ADCY3 at neuronal primary cilia underlies a common pathway for genetic predisposition to obesity.	108
29311636	2018	Loss-of-function variants in ADCY3 increase risk of obesity and type 2 diabetes.	87
29311637	2018	Loss-of-function mutations in ADCY3 cause monogenic severe obesity.	64
29921800	2018	Interaction between an ADCY3 Genetic Variant and Two Weight-Lowering Diets Affecting Body Fatness and Body Composition Outcomes Depending on Macronutrient Distribution: A Randomized Trial.	16
29311635	2018	Subcellular localization of MC4R with ADCY3 at neuronal primary cilia underlies a common pathway for genetic predisposition to obesity.	108

Citation

Dessen P

ADCY3 (adenylate cyclase 3)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/60155/teaching-explorer/

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