AMER2 (APC membrane recruitment protein 2)

2014-11-01  

Identity

HGNC
LOCATION
13q12.13
LOCUSID
ALIAS
FAM123A

Other Information

Locus ID:

NCBI: 219287
MIM: 614659
HGNC: 26360
Ensembl: ENSG00000165566

Variants:

dbSNP: 219287
ClinVar: 219287
TCGA: ENSG00000165566
COSMIC: AMER2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000165566ENST00000357816Q8N7J2
ENSG00000165566ENST00000515384Q8N7J2

Expression (GTEx)

0
5
10
15
20
25
30
35
40

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
221281702012Amer2 protein is a novel negative regulator of Wnt/β-catenin signaling involved in neuroectodermal patterning.9
228988212012Amer2 protein interacts with EB1 protein and adenomatous polyposis coli (APC) and controls microtubule stability and cell migration.8
229497352012FAM123A binds to microtubules and inhibits the guanine nucleotide exchange factor ARHGEF2 to decrease actomyosin contractility.6

Citation

Dessen P

AMER2 (APC membrane recruitment protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/60272/amer2-(apc-membrane-recruitment-protein-2)