Identity
HGNC
LOCATION
1q23.2
LOCUSID
ALIAS
HEL-S-92n,PTX2,SAP
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 325
MIM: 104770
HGNC: 584
Ensembl: ENSG00000132703
Variants:
dbSNP: 325
ClinVar: 325
TCGA: ENSG00000132703
COSMIC: APCS
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000132703 | ENST00000255040 | P02743 |
| ENSG00000132703 | ENST00000255040 | V9HWP0 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Metabolism of proteins | REACTOME | R-HSA-392499 |
| Amyloid fiber formation | REACTOME | R-HSA-977225 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36243399 | 2023 | SAP deficiency aggravates periodontitis possibly via C5a-C5aR signaling-mediated defective macrophage phagocytosis of Porphyromonas gingivalis. | 2 |
| 36884186 | 2023 | Local Pentraxin-2 Deficit Is a Feature of Intestinal Fibrosis in Crohn's Disease. | 1 |
| 37349331 | 2023 | Proteomic-based identification of APCS as candidate protein for diagnosis of patients exhibiting anti-tubercular drug induced liver injury. | 0 |
| 36243399 | 2023 | SAP deficiency aggravates periodontitis possibly via C5a-C5aR signaling-mediated defective macrophage phagocytosis of Porphyromonas gingivalis. | 2 |
| 36884186 | 2023 | Local Pentraxin-2 Deficit Is a Feature of Intestinal Fibrosis in Crohn's Disease. | 1 |
| 37349331 | 2023 | Proteomic-based identification of APCS as candidate protein for diagnosis of patients exhibiting anti-tubercular drug induced liver injury. | 0 |
| 30862745 | 2019 | Serum Amyloid P Component Binds Fungal Surface Amyloid and Decreases Human Macrophage Phagocytosis and Secretion of Inflammatory Cytokines. | 20 |
| 30862745 | 2019 | Serum Amyloid P Component Binds Fungal Surface Amyloid and Decreases Human Macrophage Phagocytosis and Secretion of Inflammatory Cytokines. | 20 |
| 28098450 | 2017 | Serum Amyloid P Component (SAP) Interactome in Human Plasma Containing Physiological Calcium Levels. | 9 |
| 28434325 | 2017 | Antiamyloidogenic and proamyloidogenic chaperone effects of C-reactive protein and serum amyloid P component. | 2 |
| 28098450 | 2017 | Serum Amyloid P Component (SAP) Interactome in Human Plasma Containing Physiological Calcium Levels. | 9 |
| 28434325 | 2017 | Antiamyloidogenic and proamyloidogenic chaperone effects of C-reactive protein and serum amyloid P component. | 2 |
| 26286643 | 2016 | Variants in RBP4 and AR genes modulate age at onset in familial amyloid polyneuropathy (FAP ATTRV30M). | 18 |
| 27428539 | 2016 | Serum Amyloid P Component Ameliorates Neurological Damage Caused by Expressing a Lysozyme Variant in the Central Nervous System of Drosophila melanogaster. | 1 |
| 27754964 | 2016 | Investigation of the inflammatory biomarkers of metabolic syndrome in adolescents. | 8 |
Citation
Dessen P
APCS (amyloid P component, serum)
Atlas Genet Cytogenet Oncol Haematol. 2014-11-01
Online version: http://atlasgeneticsoncology.org/gene/60419/gene-explorer/
