Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 116984
MIM: 606645
HGNC: 16924
Ensembl: ENSG00000047365
Variants:
dbSNP: 116984
ClinVar: 116984
TCGA: ENSG00000047365
COSMIC: ARAP2
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000047365 | ENST00000303965 | Q8WZ64 |
| ENSG00000047365 | ENST00000506189 | D6RAD6 |
| ENSG00000047365 | ENST00000511416 | D6RC39 |
| ENSG00000047365 | ENST00000618163 | A0A0C4DGW1 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Endocytosis | KEGG | ko04144 |
| Endocytosis | KEGG | hsa04144 |
| Signal Transduction | REACTOME | R-HSA-162582 |
| Signaling by Rho GTPases | REACTOME | R-HSA-194315 |
| Rho GTPase cycle | REACTOME | R-HSA-194840 |
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA164713366 | Tumor necrosis factor alpha (TNF-alpha) inhibitors | Chemical | ClinicalAnnotation | associated | PD | ||
| PA443434 | Arthritis, Rheumatoid | Disease | ClinicalAnnotation | associated | PD |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 35842667 | 2022 | The abnormal expression of circ-ARAP2 promotes ESCC progression through regulating miR-761/FOXM1 axis-mediated stemness and the endothelial-mesenchymal transition. | 4 |
| 35842667 | 2022 | The abnormal expression of circ-ARAP2 promotes ESCC progression through regulating miR-761/FOXM1 axis-mediated stemness and the endothelial-mesenchymal transition. | 4 |
| 30144359 | 2018 | ARAP2 inhibits Akt independently of its effects on focal adhesions. | 7 |
| 30144359 | 2018 | ARAP2 inhibits Akt independently of its effects on focal adhesions. | 7 |
| 25225293 | 2014 | The Arf6 GTPase-activating proteins ARAP2 and ACAP1 define distinct endosomal compartments that regulate integrin α5β1 traffic. | 30 |
| 25225293 | 2014 | The Arf6 GTPase-activating proteins ARAP2 and ACAP1 define distinct endosomal compartments that regulate integrin α5β1 traffic. | 30 |
| 23295182 | 2013 | ARAP2 signals through Arf6 and Rac1 to control focal adhesion morphology. | 20 |
| 23295182 | 2013 | ARAP2 signals through Arf6 and Rac1 to control focal adhesion morphology. | 20 |
| 20823205 | 2010 | Critical role for the host GTPase-activating protein ARAP2 in InlB-mediated entry of Listeria monocytogenes. | 12 |
| 20823205 | 2010 | Critical role for the host GTPase-activating protein ARAP2 in InlB-mediated entry of Listeria monocytogenes. | 12 |
| 17077126 | 2006 | ARAP2 effects on the actin cytoskeleton are dependent on Arf6-specific GTPase-activating-protein activity and binding to RhoA-GTP. | 39 |
| 17077126 | 2006 | ARAP2 effects on the actin cytoskeleton are dependent on Arf6-specific GTPase-activating-protein activity and binding to RhoA-GTP. | 39 |
Citation
Dessen P
ARAP2 (ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2)
Atlas Genet Cytogenet Oncol Haematol. 2014-11-01
Online version: http://atlasgeneticsoncology.org/gene/60453/arap2-(arfgap-with-rhogap-domain-ankyrin-repeat-and-ph-domain-2)
