ASIC3 (acid sensing ion channel subunit 3)

2014-11-01  

Identity

HGNC
ASIC3
LOCATION
7q36.1
LOCUSID
9311
ALIAS
ACCN3,DRASIC,SLNAC1,TNaC1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9311
MIM: 611741
HGNC: 101
Ensembl: ENSG00000213199

Variants:

dbSNP: 9311
ClinVar: 9311
TCGA: ENSG00000213199
COSMIC: ASIC3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000213199ENST00000297512Q9UHC3
ENSG00000213199ENST00000297512A0A090N8Q1
ENSG00000213199ENST00000349064Q9UHC3
ENSG00000213199ENST00000349064A0A090N7X8
ENSG00000213199ENST00000357922Q9UHC3
ENSG00000213199ENST00000357922A0A090N8Z6
ENSG00000213199ENST00000377904Q9UHC3
ENSG00000213199ENST00000468325Q9UHC3
ENSG00000213199ENST00000485929H7C5N6
ENSG00000213199ENST00000490540H7C4W0

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Inflammatory mediator regulation of TRP channelsKEGGhsa04750
Inflammatory mediator regulation of TRP channelsKEGGko04750
Transmembrane transport of small moleculesREACTOMER-HSA-382551
Ion channel transportREACTOMER-HSA-983712
Stimuli-sensing channelsREACTOMER-HSA-2672351

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
120607082002A role for ASIC3 in the modulation of high-intensity pain stimuli.99
210928622010Sensing muscle ischemia: coincident detection of acid and ATP via interplay of two ion channels.75
155747472004Acid-induced pain and its modulation in humans.73
153178152004PSD-95 and Lin-7b interact with acid-sensing ion channel-3 and have opposite effects on H+- gated current.28
228296662012Human ASIC3 channel dynamically adapts its activity to sense the extracellular pH in both acidic and alkaline directions.28
267721862016Non-acidic activation of pain-related Acid-Sensing Ion Channel 3 by lipids.24
227788542011ASIC3 channels in multimodal sensory perception.22
228424752012Asic3 is a neuronal mechanosensor for pressure-induced vasodilation that protects against pressure ulcers.22
238013322013Sea anemone peptide with uncommon β-hairpin structure inhibits acid-sensing ion channel 3 (ASIC3) and reveals analgesic activity.20
278532742016Acidic pH promotes intervertebral disc degeneration: Acid-sensing ion channel -3 as a potential therapeutic target.20

Citation

Dessen P

ASIC3 (acid sensing ion channel subunit 3)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/60572/asic3-(acid-sensing-ion-channel-subunit-3)