ASIC3 (acid sensing ion channel subunit 3)

2014-11-01  

Identity

HGNC
ASIC3
LOCATION
7q36.1
LOCUSID
9311
ALIAS
ACCN3,DRASIC,SLNAC1,TNaC1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9311
MIM: 611741
HGNC: 101
Ensembl: ENSG00000213199

Variants:

dbSNP: 9311
ClinVar: 9311
TCGA: ENSG00000213199
COSMIC: ASIC3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000213199ENST00000297512Q9UHC3
ENSG00000213199ENST00000297512A0A090N8Q1
ENSG00000213199ENST00000349064Q9UHC3
ENSG00000213199ENST00000349064A0A090N7X8
ENSG00000213199ENST00000357922Q9UHC3
ENSG00000213199ENST00000357922A0A090N8Z6
ENSG00000213199ENST00000377904Q9UHC3
ENSG00000213199ENST00000468325Q9UHC3
ENSG00000213199ENST00000485929H7C5N6
ENSG00000213199ENST00000490540H7C4W0

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Inflammatory mediator regulation of TRP channelsKEGGhsa04750
Inflammatory mediator regulation of TRP channelsKEGGko04750
Transmembrane transport of small moleculesREACTOMER-HSA-382551
Ion channel transportREACTOMER-HSA-983712
Stimuli-sensing channelsREACTOMER-HSA-2672351

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
349183852022Upregulation of acid sensing ion channels is associated with esophageal hypersensitivity in GERD.5
350861232022Lysophosphatidylcholine 16:0 mediates chronic joint pain associated to rheumatic diseases through acid-sensing ion channel 3.10
349183852022Upregulation of acid sensing ion channels is associated with esophageal hypersensitivity in GERD.5
350861232022Lysophosphatidylcholine 16:0 mediates chronic joint pain associated to rheumatic diseases through acid-sensing ion channel 3.10
336557672021Heartburn sensation in nonerosive reflux disease: pattern of superficial sensory nerves expressing TRPV1 and epithelial cells expressing ASIC3 receptors.10
338242282021ASIC1 and ASIC3 mediate cellular senescence of human nucleus pulposus mesenchymal stem cells during intervertebral disc degeneration.13
340685572021TRPV1 Responses in the Cerebellum Lobules VI, VII, VIII Using Electroacupuncture Treatment for Chronic Pain and Depression Comorbidity in a Murine Model.10
336557672021Heartburn sensation in nonerosive reflux disease: pattern of superficial sensory nerves expressing TRPV1 and epithelial cells expressing ASIC3 receptors.10
338242282021ASIC1 and ASIC3 mediate cellular senescence of human nucleus pulposus mesenchymal stem cells during intervertebral disc degeneration.13
340685572021TRPV1 Responses in the Cerebellum Lobules VI, VII, VIII Using Electroacupuncture Treatment for Chronic Pain and Depression Comorbidity in a Murine Model.10
300356582018Dual role of acid-sensing ion channels 3 in rheumatoid arthritis: destruction or protection?3
300356582018Dual role of acid-sensing ion channels 3 in rheumatoid arthritis: destruction or protection?3
281872082017Respiratory virus infection up-regulates TRPV1, TRPA1 and ASICS3 receptors on airway cells.49
285181342017ASIC1 and ASIC3 contribute to acidity-induced EMT of pancreatic cancer through activating Ca(2+)/RhoA pathway.49
286189562017Acid-sensing ion channels contribute to the effect of extracellular acidosis on proliferation and migration of A549 cells.30

Citation

Dessen P

ASIC3 (acid sensing ion channel subunit 3)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/60572/asic3-(acid-sensing-ion-channel-subunit-3)