Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 374569
MIM: 618472
HGNC: 20123
Ensembl: ENSG00000166183
Variants:
dbSNP: 374569
ClinVar: 374569
TCGA: ENSG00000166183
COSMIC: ASPG
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000166183 | ENST00000546892 | G3V1Y8 |
| ENSG00000166183 | ENST00000550583 | H0YHD3 |
| ENSG00000166183 | ENST00000551170 | H0YHG5 |
| ENSG00000166183 | ENST00000551177 | Q86U10 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Metabolism | REACTOME | R-HSA-1430728 |
| Metabolism of amino acids and derivatives | REACTOME | R-HSA-71291 |
| Amino acid synthesis and interconversion (transamination) | REACTOME | R-HSA-70614 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 35979719 | 2023 | In vivo stabilization of a less toxic asparaginase variant leads to a durable antitumor response in acute leukemia. | 5 |
| 37169557 | 2023 | L-asparaginase activity and anti-L-asparaginase antibody as biomarkers in estimating PEG-asp-related anaphylaxis risk in childhood acute lymphoblastic leukemia patients. | 0 |
| 35979719 | 2023 | In vivo stabilization of a less toxic asparaginase variant leads to a durable antitumor response in acute leukemia. | 5 |
| 37169557 | 2023 | L-asparaginase activity and anti-L-asparaginase antibody as biomarkers in estimating PEG-asp-related anaphylaxis risk in childhood acute lymphoblastic leukemia patients. | 0 |
| 34461521 | 2021 | Molecular dynamics simulations of human L-asparaginase1: Insights into structural determinants of enzymatic activity. | 0 |
| 34461521 | 2021 | Molecular dynamics simulations of human L-asparaginase1: Insights into structural determinants of enzymatic activity. | 0 |
| 29554021 | 2018 | Symptomatic Cerebral Sinovenous Thrombosis Associated With L-Asparaginase In Children With Acute Lymphoblastic Leukemia: A Single Institution Experience Over 17 Years. | 7 |
| 29554021 | 2018 | Symptomatic Cerebral Sinovenous Thrombosis Associated With L-Asparaginase In Children With Acute Lymphoblastic Leukemia: A Single Institution Experience Over 17 Years. | 7 |
| 24657844 | 2014 | Human 60-kDa lysophospholipase contains an N-terminal L-asparaginase domain that is allosterically regulated by L-asparagine. | 15 |
| 24768817 | 2014 | Elucidation of the specific function of the conserved threonine triad responsible for human L-asparaginase autocleavage and substrate hydrolysis. | 18 |
| 24657844 | 2014 | Human 60-kDa lysophospholipase contains an N-terminal L-asparaginase domain that is allosterically regulated by L-asparagine. | 15 |
| 24768817 | 2014 | Elucidation of the specific function of the conserved threonine triad responsible for human L-asparaginase autocleavage and substrate hydrolysis. | 18 |
| 22861376 | 2012 | Structures of apo and product-bound human L-asparaginase: insights into the mechanism of autoproteolysis and substrate hydrolysis. | 22 |
| 22861376 | 2012 | Structures of apo and product-bound human L-asparaginase: insights into the mechanism of autoproteolysis and substrate hydrolysis. | 22 |
| 21063096 | 2010 | 60kDa lysophospholipase, a new Sgk1 molecular partner involved in the regulation of ENaC. | 9 |
Citation
Dessen P
ASPG (asparaginase)
Atlas Genet Cytogenet Oncol Haematol. 2014-11-01
Online version: http://atlasgeneticsoncology.org/gene/60579/aspg-(asparaginase)
