ATG2A (autophagy related 2A)

2014-11-01  

Identity

HGNC
ATG2A
LOCATION
11q13.1
LOCUSID
23130
ALIAS
-
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 23130
MIM: 616225
HGNC: 29028
Ensembl: ENSG00000110046

Variants:

dbSNP: 23130
ClinVar: 23130
TCGA: ENSG00000110046
COSMIC: ATG2A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000110046ENST00000377264Q2TAZ0
ENSG00000110046ENST00000418259H7C3T2
ENSG00000110046ENST00000421419Q2TAZ0

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Autophagy - animalKEGGko04140
Autophagy - animalKEGGhsa04140
Autophagy - otherKEGGko04136
Autophagy - otherKEGGhsa04136

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
371151572023Quantitative analysis of autophagy reveals the role of ATG9 and ATG2 in autophagosome formation.17
374604672023MGCG regulates glioblastoma tumorigenicity via hnRNPK/ATG2A and promotes autophagy.0
371151572023Quantitative analysis of autophagy reveals the role of ATG9 and ATG2 in autophagosome formation.17
374604672023MGCG regulates glioblastoma tumorigenicity via hnRNPK/ATG2A and promotes autophagy.0
336192462021HIF-1α-induced expression of m6A reader YTHDF1 drives hypoxia-induced autophagy and malignancy of hepatocellular carcinoma by promoting ATG2A and ATG14 translation.134
338500232021A model for a partnership of lipid transfer proteins and scramblases in membrane expansion and organelle biogenesis.98
336192462021HIF-1α-induced expression of m6A reader YTHDF1 drives hypoxia-induced autophagy and malignancy of hepatocellular carcinoma by promoting ATG2A and ATG14 translation.134
338500232021A model for a partnership of lipid transfer proteins and scramblases in membrane expansion and organelle biogenesis.98
320092922020A conserved ATG2-GABARAP family interaction is critical for phagophore formation.41
320092922020A conserved ATG2-GABARAP family interaction is critical for phagophore formation.41
309528002019ATG2 transports lipids to promote autophagosome biogenesis.227
312713522019The autophagic membrane tether ATG2A transfers lipids between membranes.143
309528002019ATG2 transports lipids to promote autophagosome biogenesis.227
312713522019The autophagic membrane tether ATG2A transfers lipids between membranes.143
284102022017Identification of C21orf59 and ATG2A as novel determinants of renal function-related traits in Japanese by exome-wide association studies.6

Citation

Dessen P

ATG2A (autophagy related 2A)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/60597/css/gene-explorer/welcome