ATP6V1B1 (ATPase H+ transporting V1 subunit B1)

2014-11-01  

Identity

HGNC
LOCATION
2p13.3
LOCUSID
ALIAS
ATP6B1,DRTA2,RTA1B,VATB,VMA2,VPP3

Other Information

Locus ID:

NCBI: 525
MIM: 192132
HGNC: 853
Ensembl: ENSG00000116039

Variants:

dbSNP: 525
ClinVar: 525
TCGA: ENSG00000116039
COSMIC: ATP6V1B1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000116039ENST00000234396P15313
ENSG00000116039ENST00000412314C9JL73
ENSG00000116039ENST00000433895C9JZ02
ENSG00000116039ENST00000454446C9JNS9

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Pathways

PathwaySourceExternal ID
Oxidative phosphorylationKEGGko00190
mTOR signaling pathwayKEGGko04150
Vibrio cholerae infectionKEGGko05110
Epithelial cell signaling in Helicobacter pylori infectionKEGGko05120
Oxidative phosphorylationKEGGhsa00190
mTOR signaling pathwayKEGGhsa04150
Vibrio cholerae infectionKEGGhsa05110
Epithelial cell signaling in Helicobacter pylori infectionKEGGhsa05120
Metabolic pathwaysKEGGhsa01100
Collecting duct acid secretionKEGGko04966
Collecting duct acid secretionKEGGhsa04966
PhagosomeKEGGko04145
PhagosomeKEGGhsa04145
Rheumatoid arthritisKEGGko05323
Rheumatoid arthritisKEGGhsa05323
Synaptic vesicle cycleKEGGko04721
Synaptic vesicle cycleKEGGhsa04721
V-type ATPase, eukaryotesKEGGhsa_M00160
V-type ATPase, eukaryotesKEGGM00160
ROS, RNS production in phagocytesREACTOMER-HSA-1222556
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Signal TransductionREACTOMER-HSA-162582
Signaling by Insulin receptorREACTOMER-HSA-74752
Insulin receptor recyclingREACTOMER-HSA-77387
Transmembrane transport of small moleculesREACTOMER-HSA-382551
Iron uptake and transportREACTOMER-HSA-917937
Transferrin endocytosis and recyclingREACTOMER-HSA-917977
Ion channel transportREACTOMER-HSA-983712

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
353016492022Genetic heterogeneity in GJB2, COL4A3, ATP6V1B1 and EDNRB variants detected among hearing impaired families in Morocco.0
353016492022Genetic heterogeneity in GJB2, COL4A3, ATP6V1B1 and EDNRB variants detected among hearing impaired families in Morocco.0
341577942021Identification of seven exonic variants in the SLC4A1, ATP6V1B1, and ATP6V0A4 genes that alter RNA splicing by minigene assay.8
341577942021Identification of seven exonic variants in the SLC4A1, ATP6V1B1, and ATP6V0A4 genes that alter RNA splicing by minigene assay.8
317335972020ATP6V1B1 recurrent mutations in Algerian deaf patients associated with renal tubular acidosis.2
317335972020ATP6V1B1 recurrent mutations in Algerian deaf patients associated with renal tubular acidosis.2
308214272019Presence of serum autoantibodies to vacuolar H(+) -ATPase in patients with renal tubular acidosis.2
308214272019Presence of serum autoantibodies to vacuolar H(+) -ATPase in patients with renal tubular acidosis.2
290248292018Distal renal tubular acidosis in a Libyan patient: Evidence for digenic inheritance.7
290545312018The ammonia transporter RhCG modulates urinary acidification by interacting with the vacuolar proton-ATPases in renal intercalated cells.9
293108262018Changes in V-ATPase subunits of human urinary exosomes reflect the renal response to acute acid/alkali loading and the defects in distal renal tubular acidosis.0
299932762018H(+)-ATPase B1 subunit localizes to thick ascending limb and distal convoluted tubule of rodent and human kidney.10
302304132018Clinical and genetic analysis of distal renal tubular acidosis in three Chinese children.2
302566762018Five Novel Mutations in Chinese Children with Primary Distal Renal Tubular Acidosis.0
290248292018Distal renal tubular acidosis in a Libyan patient: Evidence for digenic inheritance.7

Citation

Dessen P

ATP6V1B1 (ATPase H+ transporting V1 subunit B1)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/60640/atp6v1b1-(atpase-h+-transporting-v1-subunit-b1)