Identity
HGNC
LOCATION
20q11.21
LOCUSID
ALIAS
C20orf186,LPLUNC4,RY2G5,dJ726C3.5
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 149954
MIM: 615718
HGNC: 16179
Ensembl: ENSG00000186191
Variants:
dbSNP: 149954
ClinVar: 149954
TCGA: ENSG00000186191
COSMIC: BPIFB4
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000186191 | ENST00000375483 | P59827 |
| ENSG00000186191 | ENST00000445356 | F8WEG9 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Immune System | REACTOME | R-HSA-168256 |
| Innate Immune System | REACTOME | R-HSA-168249 |
| Antimicrobial peptides | REACTOME | R-HSA-6803157 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37582912 | 2023 | BPIFB4 and its longevity-associated haplotype protect from cardiac ischemia in humans and mice. | 1 |
| 37582912 | 2023 | BPIFB4 and its longevity-associated haplotype protect from cardiac ischemia in humans and mice. | 1 |
| 35053408 | 2022 | The Longevity-Associated Variant of BPIFB4 Reduces Senescence in Glioma Cells and in Patients' Lymphocytes Favoring Chemotherapy Efficacy. | 5 |
| 35053408 | 2022 | The Longevity-Associated Variant of BPIFB4 Reduces Senescence in Glioma Cells and in Patients' Lymphocytes Favoring Chemotherapy Efficacy. | 5 |
| 31289820 | 2020 | Single systemic transfer of a human gene associated with exceptional longevity halts the progression of atherosclerosis and inflammation in ApoE knockout mice through a CXCR4-mediated mechanism. | 33 |
| 32547549 | 2020 | Circulating BPIFB4 Levels Associate With and Influence the Abundance of Reparative Monocytes and Macrophages in Long Living Individuals. | 10 |
| 32998388 | 2020 | New Insights for BPIFB4 in Cardiovascular Therapy. | 4 |
| 31289820 | 2020 | Single systemic transfer of a human gene associated with exceptional longevity halts the progression of atherosclerosis and inflammation in ApoE knockout mice through a CXCR4-mediated mechanism. | 33 |
| 32547549 | 2020 | Circulating BPIFB4 Levels Associate With and Influence the Abundance of Reparative Monocytes and Macrophages in Long Living Individuals. | 10 |
| 32998388 | 2020 | New Insights for BPIFB4 in Cardiovascular Therapy. | 4 |
| 30377885 | 2019 | Bactericidal/Permeability-Increasing Fold-Containing Family B Member 4 May Be Associated with NSAID-Induced Enteropathy. | 2 |
| 31461407 | 2019 | LAV-BPIFB4 associates with reduced frailty in humans and its transfer prevents frailty progression in old mice. | 0 |
| 30377885 | 2019 | Bactericidal/Permeability-Increasing Fold-Containing Family B Member 4 May Be Associated with NSAID-Induced Enteropathy. | 2 |
| 31461407 | 2019 | LAV-BPIFB4 associates with reduced frailty in humans and its transfer prevents frailty progression in old mice. | 0 |
| 28121621 | 2017 | The expression of the BPIFB4 and CXCR4 associates with sustained health in long-living individuals from Cilento-Italy. | 20 |
Citation
Dessen P
BPIFB4 (BPI fold containing family B member 4)
Atlas Genet Cytogenet Oncol Haematol. 2014-11-01
Online version: http://atlasgeneticsoncology.org/gene/60795/bpifb4-(bpi-fold-containing-family-b-member-4)
