Identity
HGNC
LOCATION
6p22.2
LOCUSID
ALIAS
BK14H9.1,BT2.1,BTF1,BTN2.1,DJ3E1.1
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 11120
MIM: 613590
HGNC: 1136
Ensembl: ENSG00000112763
Variants:
dbSNP: 11120
ClinVar: 11120
TCGA: ENSG00000112763
COSMIC: BTN2A1
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Immune System | REACTOME | R-HSA-168256 |
| Adaptive Immune System | REACTOME | R-HSA-1280218 |
| Butyrophilin (BTN) family interactions | REACTOME | R-HSA-8851680 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37171180 | 2023 | Mutations to the BTN2A1 Linker Region Impact Its Homodimerization and Its Cytoplasmic Interaction with Phospho-Antigen-Bound BTN3A1. | 2 |
| 37674084 | 2023 | Phosphoantigens glue butyrophilin 3A1 and 2A1 to activate Vγ9Vδ2 T cells. | 12 |
| 37171180 | 2023 | Mutations to the BTN2A1 Linker Region Impact Its Homodimerization and Its Cytoplasmic Interaction with Phospho-Antigen-Bound BTN3A1. | 2 |
| 37674084 | 2023 | Phosphoantigens glue butyrophilin 3A1 and 2A1 to activate Vγ9Vδ2 T cells. | 12 |
| 35081362 | 2022 | Ligand-induced interactions between butyrophilin 2A1 and 3A1 internal domains in the HMBPP receptor complex. | 16 |
| 35833118 | 2022 | BTN3A Targeting Vγ9Vδ2 T Cells Antimicrobial Activity Against Coxiella burnetii-Infected Cells. | 4 |
| 35081362 | 2022 | Ligand-induced interactions between butyrophilin 2A1 and 3A1 internal domains in the HMBPP receptor complex. | 16 |
| 35833118 | 2022 | BTN3A Targeting Vγ9Vδ2 T Cells Antimicrobial Activity Against Coxiella burnetii-Infected Cells. | 4 |
| 33959132 | 2021 | Soluble BTN2A1 Is a Potential Prognosis Biomarker in Pre-Treated Advanced Renal Cell Carcinoma. | 7 |
| 34260935 | 2021 | BTN2A1, an immune checkpoint targeting Vγ9Vδ2 T cell cytotoxicity against malignant cells. | 39 |
| 33959132 | 2021 | Soluble BTN2A1 Is a Potential Prognosis Biomarker in Pre-Treated Advanced Renal Cell Carcinoma. | 7 |
| 34260935 | 2021 | BTN2A1, an immune checkpoint targeting Vγ9Vδ2 T cell cytotoxicity against malignant cells. | 39 |
| 24452779 | 2014 | Association of a polymorphism of BTN2A1 with dyslipidemia in community-dwelling individuals. | 9 |
| 24452779 | 2014 | Association of a polymorphism of BTN2A1 with dyslipidemia in community-dwelling individuals. | 9 |
| 22576629 | 2012 | Synergistic effects of genetic variants of APOA5 and BTN2A1 on dyslipidemia or metabolic syndrome. | 9 |
Citation
Dessen P
BTN2A1 (butyrophilin subfamily 2 member A1)
Atlas Genet Cytogenet Oncol Haematol. 2014-11-01
Online version: http://atlasgeneticsoncology.org/gene/60836/btn2a1-(butyrophilin-subfamily-2-member-a1)
