AKAP8 (A-kinase anchoring protein 8)

2003-11-01  

Identity

HGNC
AKAP8
LOCATION
19p13.12
LOCUSID
10270
ALIAS
AKAP
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10270
MIM: 604692
HGNC: 378
Ensembl: ENSG00000105127

Variants:

dbSNP: 10270
ClinVar: 10270
TCGA: ENSG00000105127
COSMIC: AKAP8

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000105127ENST00000269701O43823
ENSG00000105127ENST00000598597M0QYL4
ENSG00000105127ENST00000599883M0QX51

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
366914072023A-Kinase Anchor Protein 95 Is Involved in ERK1/2-Elk-1 Signal Transduction in Colon Cancer.1
366914072023A-Kinase Anchor Protein 95 Is Involved in ERK1/2-Elk-1 Signal Transduction in Colon Cancer.1
319806322020The RNA-binding protein AKAP8 suppresses tumor metastasis by antagonizing EMT-associated alternative splicing.59
320287182020A-Kinase Anchoring Proteins Diminish TGF-β(1)/Cigarette Smoke-Induced Epithelial-To-Mesenchymal Transition.10
327195512020Biophysical properties of AKAP95 protein condensates regulate splicing and tumorigenesis.58
319806322020The RNA-binding protein AKAP8 suppresses tumor metastasis by antagonizing EMT-associated alternative splicing.59
320287182020A-Kinase Anchoring Proteins Diminish TGF-β(1)/Cigarette Smoke-Induced Epithelial-To-Mesenchymal Transition.10
327195512020Biophysical properties of AKAP95 protein condensates regulate splicing and tumorigenesis.58
309827502019AKAP95 Organizes a Nuclear Microdomain to Control Local cAMP for Regulating Nuclear PKA.27
309827502019AKAP95 Organizes a Nuclear Microdomain to Control Local cAMP for Regulating Nuclear PKA.27
292885302018PKA-binding domain of AKAP8 is essential for direct interaction with DPY30 protein.8
293970572018Role of A-kinase anchoring protein 95 in the regulation of cytochrome P450 family 19 subfamily A member 1 (CYP19A1) in human ovarian granulosa cells.4
292885302018PKA-binding domain of AKAP8 is essential for direct interaction with DPY30 protein.8
293970572018Role of A-kinase anchoring protein 95 in the regulation of cytochrome P450 family 19 subfamily A member 1 (CYP19A1) in human ovarian granulosa cells.4
283797802017AKAP95 interacts with nucleoporin TPR in mitosis and is important for the spindle assembly checkpoint.4

Citation

Dessen P

AKAP8 (A-kinase anchoring protein 8)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/609/akap8-(a-kinase-anchoring-protein-8)