C19orf12 (chromosome 19 open reading frame 12)

2014-11-01  

Identity

HGNC
LOCATION
19q12
LOCUSID
ALIAS
MPAN,NBIA3,NBIA4,SPG43

Other Information

Locus ID:

NCBI: 83636
MIM: 614297
HGNC: 25443
Ensembl: ENSG00000131943

Variants:

dbSNP: 83636
ClinVar: 83636
TCGA: ENSG00000131943
COSMIC: C19orf12

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000131943ENST00000323670Q9NSK7
ENSG00000131943ENST00000342680F8W6J3
ENSG00000131943ENST00000392276Q9NSK7
ENSG00000131943ENST00000392278Q9NSK7
ENSG00000131943ENST00000591243K7EPS8
ENSG00000131943ENST00000592153Q9NSK7
ENSG00000131943ENST00000614091Q9NSK7
ENSG00000131943ENST00000623113Q9NSK7

Expression (GTEx)

0
5
10
15
20
25
30
35

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
368631132023A novel C19orf12 frameshift mutation in a MPAN pedigree impairs mitochondrial function and connectivity leading to neurodegeneration.0
370040262023A novel C19ORF12 mutation in two MPAN sisters treated with deferiprone.3
368631132023A novel C19orf12 frameshift mutation in a MPAN pedigree impairs mitochondrial function and connectivity leading to neurodegeneration.0
370040262023A novel C19ORF12 mutation in two MPAN sisters treated with deferiprone.3
351827302022C19orf12 ablation causes ferroptosis in mitochondrial membrane protein-associated with neurodegeneration.6
351880902022Two cases with mitochondrial membrane protein-associated neurodegeneration: genetic features and long-term clinical follow-up.1
351827302022C19orf12 ablation causes ferroptosis in mitochondrial membrane protein-associated with neurodegeneration.6
351880902022Two cases with mitochondrial membrane protein-associated neurodegeneration: genetic features and long-term clinical follow-up.1
332600612021Dominant mitochondrial membrane protein-associated neurodegeneration (MPAN) variants cluster within a specific C19orf12 isoform.5
333942582021SPG43 and ALS-like syndrome in the same family due to compound heterozygous mutations of the C19orf12 gene: a case description and brief review.0
332600612021Dominant mitochondrial membrane protein-associated neurodegeneration (MPAN) variants cluster within a specific C19orf12 isoform.5
333942582021SPG43 and ALS-like syndrome in the same family due to compound heterozygous mutations of the C19orf12 gene: a case description and brief review.0
315184592020Brain iron and metabolic abnormalities in C19orf12 mutation carriers: A 7.0 tesla MRI study in mitochondrial membrane protein-associated neurodegeneration.7
329320222020Is there heart disease in cases of neurodegeneration associated with mutations in C19orf12?1
315184592020Brain iron and metabolic abnormalities in C19orf12 mutation carriers: A 7.0 tesla MRI study in mitochondrial membrane protein-associated neurodegeneration.7

Citation

Dessen P

C19orf12 (chromosome 19 open reading frame 12)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/61021/c19orf12-(chromosome-19-open-reading-frame-12)