AKR1B10 (aldo-keto reductase family 1 member B10)

2003-06-01 Affiliation

Identity

HGNC

AKR1B10

LOCATION

7q33

LOCUSID

57016

ALIAS

AKR1B11,AKR1B12,ALDRLn,ARL-1,ARL1,HIS,HSI

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 57016
MIM: 604707
HGNC: 382
Ensembl: ENSG00000198074

Variants:

dbSNP: 57016
ClinVar: 57016
TCGA: ENSG00000198074
COSMIC: AKR1B10

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000198074	ENST00000359579	O60218

Expression (GTEx)

100

150

200

250

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Pentose and glucuronate interconversions	KEGG	ko00040
Fructose and mannose metabolism	KEGG	ko00051
Galactose metabolism	KEGG	ko00052
Glycerolipid metabolism	KEGG	ko00561
Pentose and glucuronate interconversions	KEGG	hsa00040
Fructose and mannose metabolism	KEGG	hsa00051
Galactose metabolism	KEGG	hsa00052
Glycerolipid metabolism	KEGG	hsa00561
Metabolic pathways	KEGG	hsa01100
Signal Transduction	REACTOME	R-HSA-162582
Visual phototransduction	REACTOME	R-HSA-2187338
Retinoid metabolism and transport	REACTOME	R-HSA-975634
Metabolism	REACTOME	R-HSA-1430728
Metabolism of vitamins and cofactors	REACTOME	R-HSA-196854
Metabolism of fat-soluble vitamins	REACTOME	R-HSA-6806667

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
22014576	2011	An antioxidant response phenotype shared between hereditary and sporadic type 2 papillary renal cell carcinoma.	139
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
16127462	2005	Human aldose reductase expression accelerates diabetic atherosclerosis in transgenic mice.	73
18087047	2007	Structural basis for the high all-trans-retinaldehyde reductase activity of the tumor marker AKR1B10.	54
19643728	2009	Aldo-keto reductase family 1 member B10 promotes cell survival by regulating lipid synthesis and eliminating carbonyls.	44
12732097	2003	Human aldose reductase and human small intestine aldose reductase are efficient retinal reductases: consequences for retinoid metabolism.	43
17597105	2007	Aldo-keto reductase family 1 B10 gene silencing results in growth inhibition of colorectal cancer cells: Implication for cancer intervention.	40
18056116	2008	Aldo-keto reductase family 1 B10 affects fatty acid synthesis by regulating the stability of acetyl-CoA carboxylase-alpha in breast cancer cells.	40
22222635	2012	Overexpression and oncogenic function of aldo-keto reductase family 1B10 (AKR1B10) in pancreatic carcinoma.	33
20036025	2010	Identification and expression analysis of the aldo-ketoreductase1-B10 gene in primary malignant liver tumours.	31

Citation

Dessen P

AKR1B10 (aldo-keto reductase family 1 member B10)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/611/akr1b10-(aldo-keto-reductase-family-1-member-b10)