AKR1B10 (aldo-keto reductase family 1 member B10)

2003-06-01  

Identity

HGNC
AKR1B10
LOCATION
7q33
LOCUSID
57016
ALIAS
AKR1B11,AKR1B12,ALDRLn,ARL-1,ARL1,HIS,HSI

Other Information

Locus ID:

NCBI: 57016
MIM: 604707
HGNC: 382
Ensembl: ENSG00000198074

Variants:

dbSNP: 57016
ClinVar: 57016
TCGA: ENSG00000198074
COSMIC: AKR1B10

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000198074ENST00000359579O60218

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Pentose and glucuronate interconversionsKEGGko00040
Fructose and mannose metabolismKEGGko00051
Galactose metabolismKEGGko00052
Glycerolipid metabolismKEGGko00561
Pentose and glucuronate interconversionsKEGGhsa00040
Fructose and mannose metabolismKEGGhsa00051
Galactose metabolismKEGGhsa00052
Glycerolipid metabolismKEGGhsa00561
Metabolic pathwaysKEGGhsa01100
Signal TransductionREACTOMER-HSA-162582
Visual phototransductionREACTOMER-HSA-2187338
Retinoid metabolism and transportREACTOMER-HSA-975634
MetabolismREACTOMER-HSA-1430728
Metabolism of vitamins and cofactorsREACTOMER-HSA-196854
Metabolism of fat-soluble vitaminsREACTOMER-HSA-6806667

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
387188462024CHES1 modulated tumorigenesis and senescence of pancreas cancer cells through repressing AKR1B10.0
387188462024CHES1 modulated tumorigenesis and senescence of pancreas cancer cells through repressing AKR1B10.0
370390382023AKR1B10 regulates M2 macrophage polarization to promote the malignant phenotype of gastric cancer.2
375009272023Serum AKR1B10 as an indicator of unfavorable survival of hepatocellular carcinoma.5
375874862023Warburg effect enhanced by AKR1B10 promotes acquired resistance to pemetrexed in lung cancer-derived brain metastasis.5
377179802023RNF152 Suppresses Fatty Acid Oxidation and Metastasis of Lung Adenocarcinoma by Inhibiting IRAK1-Mediated AKR1B10 Expression.1
378233162023Aldo-keto Reductase 1B10 Restrains Cell Migration, Invasion, and Adhesion of Gastric Cancer via Regulating Integrin Subunit Alpha 5.0
370390382023AKR1B10 regulates M2 macrophage polarization to promote the malignant phenotype of gastric cancer.2
375009272023Serum AKR1B10 as an indicator of unfavorable survival of hepatocellular carcinoma.5
375874862023Warburg effect enhanced by AKR1B10 promotes acquired resistance to pemetrexed in lung cancer-derived brain metastasis.5
377179802023RNF152 Suppresses Fatty Acid Oxidation and Metastasis of Lung Adenocarcinoma by Inhibiting IRAK1-Mediated AKR1B10 Expression.1
378233162023Aldo-keto Reductase 1B10 Restrains Cell Migration, Invasion, and Adhesion of Gastric Cancer via Regulating Integrin Subunit Alpha 5.0
351638332022AKR1B10, One of the Triggers of Cytokine Storm in SARS-CoV2 Severe Acute Respiratory Syndrome.6
351788342022E2F1-mediated AUF1 upregulation promotes HCC development and enhances drug resistance via stabilization of AKR1B10.18
355634252022Plasma Aldo-Keto Reductase Family 1 Member B10 as a Biomarker Performs Well in the Diagnosis of Nonalcoholic Steatohepatitis and Fibrosis.4

Citation

Dessen P

AKR1B10 (aldo-keto reductase family 1 member B10)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/611/akr1b10-(aldo-keto-reductase-family-1-member-b10)