C4BPB (complement component 4 binding protein beta)

2014-11-01  

Identity

HGNC
C4BPB
LOCATION
1q32.1
LOCUSID
725
ALIAS
C4BP
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 725
MIM: 120831
HGNC: 1328
Ensembl: ENSG00000123843

Variants:

dbSNP: 725
ClinVar: 725
TCGA: ENSG00000123843
COSMIC: C4BPB

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000123843ENST00000243611P20851
ENSG00000123843ENST00000367076P20851
ENSG00000123843ENST00000367078P20851
ENSG00000123843ENST00000391923P20851
ENSG00000123843ENST00000452902Q5VVQ7

Expression (GTEx)

0
50
100
150
200
250
300
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Complement and coagulation cascadesKEGGko04610
Complement and coagulation cascadesKEGGhsa04610
PertussisKEGGko05133
PertussisKEGGhsa05133
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Complement cascadeREACTOMER-HSA-166658
Regulation of Complement cascadeREACTOMER-HSA-977606

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
378066022023C4BP(β-)-mediated immunomodulation attenuates inflammation in DSS-induced murine colitis and in myeloid cells from IBD patients.1
378066022023C4BP(β-)-mediated immunomodulation attenuates inflammation in DSS-induced murine colitis and in myeloid cells from IBD patients.1
281631742017Arterial Blood Pressure Induces Transient C4b-Binding Protein in Human Saphenous Vein Grafts.2
282781822017Serum amyloid A, protein Z, and C4b-binding protein β chain as new potential biomarkers for pulmonary tuberculosis.20
281631742017Arterial Blood Pressure Induces Transient C4b-Binding Protein in Human Saphenous Vein Grafts.2
282781822017Serum amyloid A, protein Z, and C4b-binding protein β chain as new potential biomarkers for pulmonary tuberculosis.20
256606182015An evaluation of association between common variants in C4BPB/C4BPA genes and schizophrenia.6
268978152015C4b-Binding Protein Deposition is Induced in Diseased Aortic Heart Valves, Coinciding with C3d.1
256606182015An evaluation of association between common variants in C4BPB/C4BPA genes and schizophrenia.6
268978152015C4b-Binding Protein Deposition is Induced in Diseased Aortic Heart Valves, Coinciding with C3d.1
233902922013The α7β0 isoform of the complement regulator C4b-binding protein induces a semimature, anti-inflammatory state in dendritic cells.18
240642152013Binding of complement inhibitor C4b-binding protein to a highly virulent Streptococcus pyogenes M1 strain is mediated by protein H and enhances adhesion to and invasion of endothelial cells.25
233902922013The α7β0 isoform of the complement regulator C4b-binding protein induces a semimature, anti-inflammatory state in dendritic cells.18
240642152013Binding of complement inhibitor C4b-binding protein to a highly virulent Streptococcus pyogenes M1 strain is mediated by protein H and enhances adhesion to and invasion of endothelial cells.25
225146782012Acquisition of complement inhibitor serine protease factor I and its cofactors C4b-binding protein and factor H by Prevotella intermedia.11

Citation

Dessen P

C4BPB (complement component 4 binding protein beta)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/61193/c4bpb-(complement-component-4-binding-protein-beta)