Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 729
MIM: 217050
HGNC: 1339
Ensembl: ENSG00000039537
Variants:
dbSNP: 729
ClinVar: 729
TCGA: ENSG00000039537
COSMIC: C6
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000039537 | ENST00000263413 | P13671 |
| ENSG00000039537 | ENST00000337836 | P13671 |
| ENSG00000039537 | ENST00000417809 | C9JC72 |
| ENSG00000039537 | ENST00000433294 | C9JX36 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA447247 | liver transplantation | Disease | ClinicalAnnotation, VariantAnnotation | ambiguous | PK | ||
| PA451578 | tacrolimus | Chemical | ClinicalAnnotation, VariantAnnotation | ambiguous | PK |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 34241972 | 2021 | Similarities and differences in the structures and proteoform profiles of the complement proteins C6 and C7. | 2 |
| 34241972 | 2021 | Similarities and differences in the structures and proteoform profiles of the complement proteins C6 and C7. | 2 |
| 28629900 | 2017 | Multiple analyses indicate the specific association of NR1I3, C6 and TNN with low hip BMD risk. | 1 |
| 28629900 | 2017 | Multiple analyses indicate the specific association of NR1I3, C6 and TNN with low hip BMD risk. | 1 |
| 27173880 | 2016 | Recipient C6 rs9200 genotype is associated with hepatocellular carcinoma recurrence after orthotopic liver transplantation in a Han Chinese population. | 5 |
| 27405496 | 2016 | Polymorphisms in complement genes and risk of preeclampsia in Taiyuan, China. | 7 |
| 27173880 | 2016 | Recipient C6 rs9200 genotype is associated with hepatocellular carcinoma recurrence after orthotopic liver transplantation in a Han Chinese population. | 5 |
| 27405496 | 2016 | Polymorphisms in complement genes and risk of preeclampsia in Taiyuan, China. | 7 |
| 25735751 | 2015 | Exposure to the complement C5b-9 complex sensitizes 661W photoreceptor cells to both apoptosis and necroptosis. | 8 |
| 25735751 | 2015 | Exposure to the complement C5b-9 complex sensitizes 661W photoreceptor cells to both apoptosis and necroptosis. | 8 |
| 22267737 | 2012 | Structure of complement C6 suggests a mechanism for initiation and unidirectional, sequential assembly of membrane attack complex (MAC). | 36 |
| 22288589 | 2012 | Complete deficiency of the sixth complement component (C6Q0), susceptibility to Neisseria meningitidis infections and analysis of the frequencies of C6Q0 gene defects in South Africans. | 8 |
| 22500023 | 2012 | Crystal structure of C5b-6 suggests structural basis for priming assembly of the membrane attack complex. | 27 |
| 22267737 | 2012 | Structure of complement C6 suggests a mechanism for initiation and unidirectional, sequential assembly of membrane attack complex (MAC). | 36 |
| 22288589 | 2012 | Complete deficiency of the sixth complement component (C6Q0), susceptibility to Neisseria meningitidis infections and analysis of the frequencies of C6Q0 gene defects in South Africans. | 8 |
Citation
Dessen P
C6 (complement C6)
Atlas Genet Cytogenet Oncol Haematol. 2014-11-01
Online version: http://atlasgeneticsoncology.org/gene/61230/c6-(complement-c6)
