C8G (complement C8 gamma chain)

2014-11-01  

Identity

HGNC
LOCATION
9q34.3
LOCUSID
ALIAS
C8C

Other Information

Locus ID:

NCBI: 733
MIM: 120930
HGNC: 1354
Ensembl: ENSG00000176919

Variants:

dbSNP: 733
ClinVar: 733
TCGA: ENSG00000176919
COSMIC: C8G

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000176919ENST00000371634P07360
ENSG00000176919ENST00000484376A0A3B3ITY0
ENSG00000176919ENST00000649480A0A3B3ITK5

Expression (GTEx)

0
50
100
150
200
250
300
350
400

Pathways

PathwaySourceExternal ID
Complement and coagulation cascadesKEGGko04610
Systemic lupus erythematosusKEGGko05322
Complement and coagulation cascadesKEGGhsa04610
Systemic lupus erythematosusKEGGhsa05322
Prion diseasesKEGGko05020
Prion diseasesKEGGhsa05020
AmoebiasisKEGGko05146
AmoebiasisKEGGhsa05146
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Complement cascadeREACTOMER-HSA-166658
Terminal pathway of complementREACTOMER-HSA-166665
Regulation of Complement cascadeREACTOMER-HSA-977606

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
365091662023Elevated complement component 8 gamma levels in astrocyte-derived exosomes are associated with cognitive impairment in obstructive sleep apnea patients without dementia.0
365091662023Elevated complement component 8 gamma levels in astrocyte-derived exosomes are associated with cognitive impairment in obstructive sleep apnea patients without dementia.0
295323262018Comprehensive Proteoform Characterization of Plasma Complement Component C8αβγ by Hybrid Mass Spectrometry Approaches.13
295323262018Comprehensive Proteoform Characterization of Plasma Complement Component C8αβγ by Hybrid Mass Spectrometry Approaches.13
204069642010Risk of meningioma and common variation in genes related to innate immunity.21
204387852010Polymorphisms in innate immunity genes and risk of childhood leukemia.12
204069642010Risk of meningioma and common variation in genes related to innate immunity.21
204387852010Polymorphisms in innate immunity genes and risk of childhood leukemia.12
190483112009A disulfide linked model of the complement protein C8gamma complexed with C8alpha indel peptide.0
194235402009Common variation in genes related to innate immunity and risk of adult glioma.35
190483112009A disulfide linked model of the complement protein C8gamma complexed with C8alpha indel peptide.0
194235402009Common variation in genes related to innate immunity and risk of adult glioma.35
184405552008Crystal structure of the MACPF domain of human complement protein C8 alpha in complex with the C8 gamma subunit.36
184405552008Crystal structure of the MACPF domain of human complement protein C8 alpha in complex with the C8 gamma subunit.36
174520332007Structural features of the ligand binding site on human complement protein C8gamma: a member of the lipocalin family.5

Citation

Dessen P

C8G (complement C8 gamma chain)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/61279/c8g-(complement-c8-gamma-chain)