Identity
HGNC
LOCATION
7q21.11
LOCUSID
ALIAS
CACNA2,CACNL2A,CCHL2A,LINC01112,lncRNA-N3
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 781
MIM: 114204
HGNC: 1399
Ensembl: ENSG00000153956
Variants:
dbSNP: 781
ClinVar: 781
TCGA: ENSG00000153956
COSMIC: CACNA2D1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000153956 | ENST00000356253 | P54289 |
| ENSG00000153956 | ENST00000356860 | P54289 |
| ENSG00000153956 | ENST00000423588 | E7ERK3 |
| ENSG00000153956 | ENST00000443883 | H0Y715 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA448871 | celecoxib | Chemical | Pathway | associated | 22336956 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38536483 | 2024 | CACNA2D1 regulates the progression and influences the microenvironment of colon cancer. | 1 |
| 38536483 | 2024 | CACNA2D1 regulates the progression and influences the microenvironment of colon cancer. | 1 |
| 37196677 | 2023 | EMC chaperone-Ca(V) structure reveals an ion channel assembly intermediate. | 11 |
| 37196677 | 2023 | EMC chaperone-Ca(V) structure reveals an ion channel assembly intermediate. | 11 |
| 35293990 | 2022 | Biallelic CACNA2D1 loss-of-function variants cause early-onset developmental epileptic encephalopathy. | 11 |
| 35293990 | 2022 | Biallelic CACNA2D1 loss-of-function variants cause early-onset developmental epileptic encephalopathy. | 11 |
| 33415786 | 2021 | Ca(V) α2δ Autoimmune Encephalitis: A Novel Antibody and its Characteristics. | 4 |
| 33707423 | 2021 | Calcium channel α2δ1 subunit is a functional marker and therapeutic target for tumor-initiating cells in non-small cell lung cancer. | 11 |
| 33896833 | 2021 | The α2δ1 subunit of the voltage-gated calcium channel acts as a potential candidate for breast cancer tumor initial cells biomarker. | 5 |
| 34049015 | 2021 | Calcium Channel Subunit α2δ-1 as a Potential Biomarker Reflecting Illness Severity and Neuroinflammation in Patients with Acute Ischemic Stroke. | 5 |
| 33415786 | 2021 | Ca(V) α2δ Autoimmune Encephalitis: A Novel Antibody and its Characteristics. | 4 |
| 33707423 | 2021 | Calcium channel α2δ1 subunit is a functional marker and therapeutic target for tumor-initiating cells in non-small cell lung cancer. | 11 |
| 33896833 | 2021 | The α2δ1 subunit of the voltage-gated calcium channel acts as a potential candidate for breast cancer tumor initial cells biomarker. | 5 |
| 34049015 | 2021 | Calcium Channel Subunit α2δ-1 as a Potential Biomarker Reflecting Illness Severity and Neuroinflammation in Patients with Acute Ischemic Stroke. | 5 |
| 31725046 | 2020 | MicroRNA-107 inhibits proliferation and invasion of laryngeal squamous cell carcinoma cells by targeting CACNA2D1 in vitro. | 14 |
Citation
Dessen P
CACNA2D1 (calcium voltage-gated channel auxiliary subunit alpha2delta 1)
Atlas Genet Cytogenet Oncol Haematol. 2014-11-01
Online version: http://atlasgeneticsoncology.org/gene/61366/cacna2d1-(calcium-voltage-gated-channel-auxiliary-subunit-alpha2delta-1)
