CAPN7 (calpain 7)

2014-11-01  

Identity

HGNC
CAPN7
LOCATION
3p25.1
LOCUSID
23473
ALIAS
CALPAIN7,PALBH
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 23473
MIM: 606400
HGNC: 1484
Ensembl: ENSG00000131375

Variants:

dbSNP: 23473
ClinVar: 23473
TCGA: ENSG00000131375
COSMIC: CAPN7

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000131375ENST00000253693Q9Y6W3
ENSG00000131375ENST00000415565H7C1B7
ENSG00000131375ENST00000418994F8WCZ1
ENSG00000131375ENST00000443567H7C0F1
ENSG00000131375ENST00000457023F8WDQ3

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Extracellular matrix organizationREACTOMER-HSA-1474244
Degradation of the extracellular matrixREACTOMER-HSA-1474228

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
351914642022Calpain7 negatively regulates human endometrial stromal cell decidualization in EMs by promoting FoxO1 nuclear exclusion via hydrolyzing AKT1.2
351914642022Calpain7 negatively regulates human endometrial stromal cell decidualization in EMs by promoting FoxO1 nuclear exclusion via hydrolyzing AKT1.2
249531352014Involvement of calpain-7 in epidermal growth factor receptor degradation via the endosomal sorting pathway.8
249531352014Involvement of calpain-7 in epidermal growth factor receptor degradation via the endosomal sorting pathway.8
234971132013Analysis of limited proteolytic activity of calpain-7 using non-physiological substrates in mammalian cells.3
238555902013CAPN 7 promotes the migration and invasion of human endometrial stromal cell by regulating matrix metalloproteinase 2 activity.14
234971132013Analysis of limited proteolytic activity of calpain-7 using non-physiological substrates in mammalian cells.3
238555902013CAPN 7 promotes the migration and invasion of human endometrial stromal cell by regulating matrix metalloproteinase 2 activity.14
216169152011Calpain-7 binds to CHMP1B at its second α-helical region and forms a ternary complex with IST1.3
216169152011Calpain-7 binds to CHMP1B at its second α-helical region and forms a ternary complex with IST1.3
208494182010Autolytic activity of human calpain 7 is enhanced by ESCRT-III-related protein IST1 through MIT-MIM interaction.16
208494182010Autolytic activity of human calpain 7 is enhanced by ESCRT-III-related protein IST1 through MIT-MIM interaction.16

Citation

Dessen P

CAPN7 (calpain 7)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/61410/capn7-(calpain-7)