CCT4 (chaperonin containing TCP1 subunit 4)

2014-11-01  

Identity

HGNC
LOCATION
2p15
LOCUSID
ALIAS
CCT-DELTA,Cctd,SRB
FUSION GENES

Other Information

Locus ID:

NCBI: 10575
MIM: 605142
HGNC: 1617
Ensembl: ENSG00000115484

Variants:

dbSNP: 10575
ClinVar: 10575
TCGA: ENSG00000115484
COSMIC: CCT4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000115484ENST00000394440P50991
ENSG00000115484ENST00000544079P50991

Expression (GTEx)

0
50
100
150
200
250
300

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Protein foldingREACTOMER-HSA-391251
Chaperonin-mediated protein foldingREACTOMER-HSA-390466
Cooperation of Prefoldin and TriC/CCT in actin and tubulin foldingREACTOMER-HSA-389958
Prefoldin mediated transfer of substrate to CCT/TriCREACTOMER-HSA-389957
Formation of tubulin folding intermediates by CCT/TriCREACTOMER-HSA-389960
Folding of actin by CCT/TriCREACTOMER-HSA-390450
Association of TriC/CCT with target proteins during biosynthesisREACTOMER-HSA-390471
Organelle biogenesis and maintenanceREACTOMER-HSA-1852241
Cilium AssemblyREACTOMER-HSA-5617833
Cargo trafficking to the periciliary membraneREACTOMER-HSA-5620920
BBSome-mediated cargo-targeting to ciliumREACTOMER-HSA-5620922
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta foldingREACTOMER-HSA-6814122

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
236129812013Human CCT4 and CCT5 chaperonin subunits expressed in Escherichia coli form biologically active homo-oligomers.26
243205612014The chaperonin CCT interacts with and mediates the correct folding and activity of three subunits of translation initiation factor eIF3: b, i and h.6

Citation

Dessen P

CCT4 (chaperonin containing TCP1 subunit 4)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/61601/cct4-(chaperonin-containing-tcp1-subunit-4)