CD300C (CD300c molecule)

2014-11-01  

Identity

HGNC
LOCATION
17q25.1
LOCUSID
ALIAS
CLM-6,CMRF-35,CMRF-35A,CMRF35,CMRF35-A1,CMRF35A,CMRF35A1,IGSF16,LIR

Other Information

Locus ID:

NCBI: 10871
MIM: 606786
HGNC: 19320
Ensembl: ENSG00000167850

Variants:

dbSNP: 10871
ClinVar: 10871
TCGA: ENSG00000167850
COSMIC: CD300C

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000167850ENST00000330793Q08708

Expression (GTEx)

0
5
10
15
20
25

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellREACTOMER-HSA-198933

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
206569212010Expression and function of CD300 in NK cells.29
185352062008CD300a/c regulate type I interferon and TNF-alpha secretion by human plasmacytoid dendritic cells stimulated with TLR7 and TLR9 ligands.28
233721572013Human CD300C delivers an Fc receptor-γ-dependent activating signal in mast cells and monocytes and differs from CD300A in ligand recognition.15
220469702011Differential expression of CD300a/c on human TH1 and TH17 cells.11
270403282016CD300c is uniquely expressed on CD56 bright Natural Killer Cells and differs from CD300a upon ligand recognition.11
235715072013CD300c is an activating receptor expressed on human monocytes.7
299065282019CD300c costimulates IgE-mediated basophil activation, and its expression is increased in patients with cow's milk allergy.4
304984972018A CD300c-Fc Fusion Protein Inhibits T Cell Immunity.2
124560262002CMRF-35A, CMRF-35H: potential new CD.1

Citation

Dessen P

CD300C (CD300c molecule)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/61619/cd300c-(cd300c-molecule)