CD300LF (CD300 molecule like family member f)

2014-11-01  

Identity

HGNC
LOCATION
17q25.1
LOCUSID
ALIAS
CD300f,CLM-1,CLM1,IREM-1,IREM1,IgSF13,LMIR3,NKIR

Other Information

Locus ID:

NCBI: 146722
MIM: 609807
HGNC: 29883
Ensembl: ENSG00000186074

Variants:

dbSNP: 146722
ClinVar: 146722
TCGA: ENSG00000186074
COSMIC: CD300LF

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000186074ENST00000301573Q8TDQ1
ENSG00000186074ENST00000326165Q8TDQ1
ENSG00000186074ENST00000343125Q8TDQ1
ENSG00000186074ENST00000361254Q8TDQ1
ENSG00000186074ENST00000462044Q8TDQ1
ENSG00000186074ENST00000464910Q8TDQ1
ENSG00000186074ENST00000469092Q8TDQ1
ENSG00000186074ENST00000581500Q8TDQ1
ENSG00000186074ENST00000583937J3KS52

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellREACTOMER-HSA-198933

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
200315772009Novel loci, including those related to Crohn disease, psoriasis, and inflammation, identified in a genome-wide association study of fibrinogen in 17 686 women: the Women's Genome Health Study.34
155497312004IREM-1 is a novel inhibitory receptor expressed by myeloid cells.25
172023422007The IREM-1 (CD300f) inhibitory receptor associates with the p85alpha subunit of phosphoinositide 3-kinase.22
220439232012CD300a and CD300f differentially regulate the MyD88 and TRIF-mediated TLR signalling pathways through activation of SHP-1 and/or SHP-2 in human monocytic cell lines.16
271184912017A key requirement for CD300f in innate immune responses of eosinophils in colitis.13
215368012011CD300F blocks both MyD88 and TRIF-mediated TLR signaling through activation of Src homology region 2 domain-containing phosphatase 1.12
219513262012Overexpression of the immunoreceptor CD300f has a neuroprotective role in a model of acute brain injury.9
230728612013CD300 molecule regulation of human dendritic cell functions.8
151840702004IgSF13, a novel human inhibitory receptor of the immunoglobulin superfamily, is preferentially expressed in dendritic cells and monocytes.7
206460062010Immune receptor expressed on myeloid cells 1 (IREM-1) inhibits B cell activation factor (BAFF)-mediated inflammatory regulation of THP-1 cells through modulation of the activities of extracellular regulated kinase (ERK).7

Citation

Dessen P

CD300LF (CD300 molecule like family member f)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/61623/cd300lf-(cd300-molecule-like-family-member-f)