CENPN (centromere protein N)

2014-11-01  

Identity

HGNC
LOCATION
16q23.2
LOCUSID
ALIAS
BM039,C16orf60,CENP-N,ICEN32

Other Information

Locus ID:

NCBI: 55839
MIM: 611509
HGNC: 30873
Ensembl: ENSG00000166451

Variants:

dbSNP: 55839
ClinVar: 55839
TCGA: ENSG00000166451
COSMIC: CENPN

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000166451ENST00000299572Q96H22
ENSG00000166451ENST00000305850Q96H22
ENSG00000166451ENST00000393335Q96H22
ENSG00000166451ENST00000428963Q96H22
ENSG00000166451ENST00000439957Q96H22
ENSG00000166451ENST00000562943H3BRU7
ENSG00000166451ENST00000564669H3BMC7
ENSG00000166451ENST00000568445H3BMD5

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases Activate ForminsREACTOMER-HSA-5663220
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
M PhaseREACTOMER-HSA-68886
Mitotic PrometaphaseREACTOMER-HSA-68877
Resolution of Sister Chromatid CohesionREACTOMER-HSA-2500257
Mitotic Metaphase and AnaphaseREACTOMER-HSA-2555396
Mitotic AnaphaseREACTOMER-HSA-68882
Separation of Sister ChromatidsREACTOMER-HSA-2467813
Chromosome MaintenanceREACTOMER-HSA-73886
Nucleosome assemblyREACTOMER-HSA-774815
Deposition of new CENPA-containing nucleosomes at the centromereREACTOMER-HSA-606279

References

Pubmed IDYearTitleCitations
195432702009Centromere assembly requires the direct recognition of CENP-A nucleosomes by CENP-N.115
266986612015The CENP-L-N Complex Forms a Critical Node in an Integrated Meshwork of Interactions at the Centromere-Kinetochore Interface.51
292694202018Structural mechanisms of centromeric nucleosome recognition by the kinetochore protein CENP-N.30
292807352017Decoding the centromeric nucleosome through CENP-N.27
221009162011Dynamics of CENP-N kinetochore binding during the cell cycle.26
293435522018Constitutive centromere-associated network contacts confer differential stability on CENP-A nucleosomes in vitro and in the cell.8

Citation

Dessen P

CENPN (centromere protein N)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/61708/cenpn-(centromere-protein-n)