CENPN (centromere protein N)

2014-11-01  

Identity

HGNC
LOCATION
16q23.2
LOCUSID
ALIAS
BM039,C16orf60,CENP-N,ICEN32

Other Information

Locus ID:

NCBI: 55839
MIM: 611509
HGNC: 30873
Ensembl: ENSG00000166451

Variants:

dbSNP: 55839
ClinVar: 55839
TCGA: ENSG00000166451
COSMIC: CENPN

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000166451ENST00000299572Q96H22
ENSG00000166451ENST00000305850Q96H22
ENSG00000166451ENST00000393335Q96H22
ENSG00000166451ENST00000428963Q96H22
ENSG00000166451ENST00000439957Q96H22
ENSG00000166451ENST00000562943H3BRU7
ENSG00000166451ENST00000564669H3BMC7
ENSG00000166451ENST00000568445H3BMD5

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases Activate ForminsREACTOMER-HSA-5663220
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
M PhaseREACTOMER-HSA-68886
Mitotic PrometaphaseREACTOMER-HSA-68877
Resolution of Sister Chromatid CohesionREACTOMER-HSA-2500257
Mitotic Metaphase and AnaphaseREACTOMER-HSA-2555396
Mitotic AnaphaseREACTOMER-HSA-68882
Separation of Sister ChromatidsREACTOMER-HSA-2467813
Chromosome MaintenanceREACTOMER-HSA-73886
Nucleosome assemblyREACTOMER-HSA-774815
Deposition of new CENPA-containing nucleosomes at the centromereREACTOMER-HSA-606279

References

Pubmed IDYearTitleCitations
371270482023Knockdown of CENPN Inhibits Glucose Metabolism and Induces G1 Arrest in Esophageal Cancer Cells by Regulating PI3K/AKT Signaling Pathway.1
373656812023Dynamic phosphorylation of CENP-N by CDK1 guides accurate chromosome segregation in mitosis.1
376972452023Clinical implications and immune features of CENPN in breast cancer.0
371270482023Knockdown of CENPN Inhibits Glucose Metabolism and Induces G1 Arrest in Esophageal Cancer Cells by Regulating PI3K/AKT Signaling Pathway.1
373656812023Dynamic phosphorylation of CENP-N by CDK1 guides accurate chromosome segregation in mitosis.1
376972452023Clinical implications and immune features of CENPN in breast cancer.0
351503992022Centromere protein N promotes lung adenocarcinoma progression by activating PI3K/AKT signaling pathway.2
354225192022CENP-N promotes the compaction of centromeric chromatin.17
351503992022Centromere protein N promotes lung adenocarcinoma progression by activating PI3K/AKT signaling pathway.2
354225192022CENP-N promotes the compaction of centromeric chromatin.17
330651122021The Elusive Structure of Centro-Chromatin: Molecular Order or Dynamic Heterogenetity?6
330651122021The Elusive Structure of Centro-Chromatin: Molecular Order or Dynamic Heterogenetity?6
292694202018Structural mechanisms of centromeric nucleosome recognition by the kinetochore protein CENP-N.63
293435522018Constitutive centromere-associated network contacts confer differential stability on CENP-A nucleosomes in vitro and in the cell.18
292694202018Structural mechanisms of centromeric nucleosome recognition by the kinetochore protein CENP-N.63

Citation

Dessen P

CENPN (centromere protein N)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/61708/submit-meetings/new-content/