CENPQ (centromere protein Q)

2014-11-01  

Identity

HGNC
LOCATION
6p12.3
LOCUSID
ALIAS
C6orf139,CENP-Q
FUSION GENES

Other Information

Locus ID:

NCBI: 55166
MIM: 611506
HGNC: 21347
Ensembl: ENSG00000031691

Variants:

dbSNP: 55166
ClinVar: 55166
TCGA: ENSG00000031691
COSMIC: CENPQ

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000031691ENST00000335783Q7L2Z9

Expression (GTEx)

0
5
10
15
20
25

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases Activate ForminsREACTOMER-HSA-5663220
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
M PhaseREACTOMER-HSA-68886
Mitotic PrometaphaseREACTOMER-HSA-68877
Resolution of Sister Chromatid CohesionREACTOMER-HSA-2500257
Mitotic Metaphase and AnaphaseREACTOMER-HSA-2555396
Mitotic AnaphaseREACTOMER-HSA-68882
Separation of Sister ChromatidsREACTOMER-HSA-2467813
Chromosome MaintenanceREACTOMER-HSA-73886
Nucleosome assemblyREACTOMER-HSA-774815
Deposition of new CENPA-containing nucleosomes at the centromereREACTOMER-HSA-606279

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
214545802011Mammalian polo-like kinase 1-dependent regulation of the PBIP1-CENP-Q complex at kinetochores.15
230285902012Step-wise assembly, maturation and dynamic behavior of the human CENP-P/O/R/Q/U kinetochore sub-complex.14
253955792015Chromosome congression is promoted by CENP-Q- and CENP-E-dependent pathways.13
256708582015Mammalian Polo-like kinase 1 (Plk1) promotes proper chromosome segregation by phosphorylating and delocalizing the PBIP1·CENP-Q complex from kinetochores.6

Citation

Dessen P

CENPQ (centromere protein Q)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/61711/cenpq-(centromere-protein-q)