Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 23177
MIM: 616889
HGNC: 29076
Ensembl: ENSG00000011523
Variants:
dbSNP: 23177
ClinVar: 23177
TCGA: ENSG00000011523
COSMIC: CEP68
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000011523 | ENST00000260569 | Q76N32 |
| ENSG00000011523 | ENST00000377990 | Q76N32 |
| ENSG00000011523 | ENST00000537589 | Q5HYA6 |
Expression (GTEx)
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA443450 | Asthma | Disease | ClinicalAnnotation | associated | PD | ||
| PA448497 | aspirin | Chemical | ClinicalAnnotation | associated | PD |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 30093714 | 2019 | Polymorphisms in CEP68 gene associated with risk of immediate selective reactions to non-steroidal anti-inflammatory drugs. | 2 |
| 30093714 | 2019 | Polymorphisms in CEP68 gene associated with risk of immediate selective reactions to non-steroidal anti-inflammatory drugs. | 2 |
| 29463719 | 2018 | STED nanoscopy of the centrosome linker reveals a CEP68-organized, periodic rootletin network anchored to a C-Nap1 ring at centrioles. | 35 |
| 29463719 | 2018 | STED nanoscopy of the centrosome linker reveals a CEP68-organized, periodic rootletin network anchored to a C-Nap1 ring at centrioles. | 35 |
| 28089774 | 2017 | Rootletin prevents Cep68 from VHL-mediated proteasomal degradation to maintain centrosome cohesion. | 9 |
| 28578000 | 2017 | Centrosomal MCM7 strengthens the Cep68-VHL interaction and excessive MCM7 leads to centrosome splitting resulting from increase in Cep68 ubiquitination and proteasomal degradation. | 5 |
| 28089774 | 2017 | Rootletin prevents Cep68 from VHL-mediated proteasomal degradation to maintain centrosome cohesion. | 9 |
| 28578000 | 2017 | Centrosomal MCM7 strengthens the Cep68-VHL interaction and excessive MCM7 leads to centrosome splitting resulting from increase in Cep68 ubiquitination and proteasomal degradation. | 5 |
| 25503564 | 2015 | Degradation of Cep68 and PCNT cleavage mediate Cep215 removal from the PCM to allow centriole separation, disengagement and licensing. | 41 |
| 25704143 | 2015 | Cep68 can be regulated by Nek2 and SCF complex. | 14 |
| 25503564 | 2015 | Degradation of Cep68 and PCNT cleavage mediate Cep215 removal from the PCM to allow centriole separation, disengagement and licensing. | 41 |
| 25704143 | 2015 | Cep68 can be regulated by Nek2 and SCF complex. | 14 |
| 24554434 | 2014 | Centlein mediates an interaction between C-Nap1 and Cep68 to maintain centrosome cohesion. | 33 |
| 24618698 | 2014 | Variants of CEP68 gene are associated with acute urticaria/angioedema induced by multiple non-steroidal anti-inflammatory drugs. | 2 |
| 24554434 | 2014 | Centlein mediates an interaction between C-Nap1 and Cep68 to maintain centrosome cohesion. | 33 |
Citation
Dessen P
CEP68 (centrosomal protein 68)
Atlas Genet Cytogenet Oncol Haematol. 2014-11-01
Online version: http://atlasgeneticsoncology.org/gene/61727/cep68-(centrosomal-protein-68)
