CEP68 (centrosomal protein 68)

2014-11-01  

Identity

HGNC
LOCATION
2p14
LOCUSID
ALIAS
KIAA0582
FUSION GENES

Other Information

Locus ID:

NCBI: 23177
MIM: 616889
HGNC: 29076
Ensembl: ENSG00000011523

Variants:

dbSNP: 23177
ClinVar: 23177
TCGA: ENSG00000011523
COSMIC: CEP68

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000011523ENST00000260569Q76N32
ENSG00000011523ENST00000377990Q76N32
ENSG00000011523ENST00000537589Q5HYA6

Expression (GTEx)

0
5
10
15
20
25
30

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA443450AsthmaDiseaseClinicalAnnotationassociatedPD
PA448497aspirinChemicalClinicalAnnotationassociatedPD

References

Pubmed IDYearTitleCitations
180426212007Cep68 and Cep215 (Cdk5rap2) are required for centrosome cohesion.82
255035642015Degradation of Cep68 and PCNT cleavage mediate Cep215 removal from the PCM to allow centriole separation, disengagement and licensing.28
245544342014Centlein mediates an interaction between C-Nap1 and Cep68 to maintain centrosome cohesion.21
210722012010Genome-wide and follow-up studies identify CEP68 gene variants associated with risk of aspirin-intolerant asthma.20
210722012010Genome-wide and follow-up studies identify CEP68 gene variants associated with risk of aspirin-intolerant asthma.20
294637192018STED nanoscopy of the centrosome linker reveals a CEP68-organized, periodic rootletin network anchored to a C-Nap1 ring at centrioles.12
257041432015Cep68 can be regulated by Nek2 and SCF complex.9
175705162007Phosphoproteomics identified Endofin, DCBLD2, and KIAA0582 as novel tyrosine phosphorylation targets of EGF signaling and Iressa in human cancer cells.7
280897742017Rootletin prevents Cep68 from VHL-mediated proteasomal degradation to maintain centrosome cohesion.5
285780002017Centrosomal MCM7 strengthens the Cep68-VHL interaction and excessive MCM7 leads to centrosome splitting resulting from increase in Cep68 ubiquitination and proteasomal degradation.2

Citation

Dessen P

CEP68 (centrosomal protein 68)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/61727/cep68-(centrosomal-protein-68)