CHIA (chitinase acidic)

2014-11-01  

Identity

HGNC
LOCATION
1p13.2
LOCUSID
ALIAS
AMCASE,CHIT2,TSA1902
FUSION GENES

Other Information

Locus ID:

NCBI: 27159
MIM: 606080
HGNC: 17432
Ensembl: ENSG00000134216

Variants:

dbSNP: 27159
ClinVar: 27159
TCGA: ENSG00000134216
COSMIC: CHIA

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000134216ENST00000343320Q9BZP6
ENSG00000134216ENST00000352594H7BXH6
ENSG00000134216ENST00000353665Q9BZP6
ENSG00000134216ENST00000369740Q9BZP6
ENSG00000134216ENST00000422815Q5VUV5
ENSG00000134216ENST00000430615Q9BZP6
ENSG00000134216ENST00000451398Q9BZP6
ENSG00000134216ENST00000483391Q9BZP6
ENSG00000134216ENST00000489524E9PLJ2

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100

Pathways

PathwaySourceExternal ID
Amino sugar and nucleotide sugar metabolismKEGGko00520
Amino sugar and nucleotide sugar metabolismKEGGhsa00520
Metabolic pathwaysKEGGhsa01100
MetabolismREACTOMER-HSA-1430728
Metabolism of carbohydratesREACTOMER-HSA-71387

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA131285571aspirin-induced asthmaDiseaseClinicalAnnotationassociatedPD
PA448497aspirinChemicalClinicalAnnotationassociatedPD

References

Pubmed IDYearTitleCitations
301171662018Acidic mammalian chitinase tuning after enteric helminths eradication in inflammatory respiratory disease patients.0
301171662018Acidic mammalian chitinase tuning after enteric helminths eradication in inflammatory respiratory disease patients.0
292331082017Association between risk of asthma and gene polymorphisms in CHI3L1 and CHIA: a systematic meta-analysis.6
292331082017Association between risk of asthma and gene polymorphisms in CHI3L1 and CHIA: a systematic meta-analysis.6
277027772016Loss and Gain of Human Acidic Mammalian Chitinase Activity by Nonsynonymous SNPs.25
279777242016Genetic Variants in CHIA and CHI3L1 Are Associated with the IgE Response to the Ascaris Resistance Marker ABA-1 and the Birch Pollen Allergen Bet v 1.4
277027772016Loss and Gain of Human Acidic Mammalian Chitinase Activity by Nonsynonymous SNPs.25
279777242016Genetic Variants in CHIA and CHI3L1 Are Associated with the IgE Response to the Ascaris Resistance Marker ABA-1 and the Birch Pollen Allergen Bet v 1.4
249039942014Proteins induced by telomere dysfunction are associated with human IgA nephropathy.7
249039942014Proteins induced by telomere dysfunction are associated with human IgA nephropathy.7
231292582013Evaluation of AMCase and CHIT-1 expression in monocyte macrophages lineage.21
241196142013Transcriptome signatures in Helicobacter pylori-infected mucosa identifies acidic mammalian chitinase loss as a corpus atrophy marker.30
231292582013Evaluation of AMCase and CHIT-1 expression in monocyte macrophages lineage.21
241196142013Transcriptome signatures in Helicobacter pylori-infected mucosa identifies acidic mammalian chitinase loss as a corpus atrophy marker.30
222007672012Genetic association between human chitinases and lung function in COPD.9

Citation

Dessen P

CHIA (chitinase acidic)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/61796/chia-(chitinase-acidic)