CHST14 (carbohydrate sulfotransferase 14)

2014-11-01  

Identity

HGNC
LOCATION
15q15.1
LOCUSID
ALIAS
ATCS,D4ST1,EDSMC1,HNK1ST
FUSION GENES

Other Information

Locus ID:

NCBI: 113189
MIM: 608429
HGNC: 24464
Ensembl: ENSG00000169105

Variants:

dbSNP: 113189
ClinVar: 113189
TCGA: ENSG00000169105
COSMIC: CHST14

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000169105ENST00000306243Q8NCH0
ENSG00000169105ENST00000559991H0YN65

Expression (GTEx)

0
5
10
15
20
25
30
35

Pathways

PathwaySourceExternal ID
Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfateKEGGko00532
Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfateKEGGhsa00532
MetabolismREACTOMER-HSA-1430728
Metabolism of carbohydratesREACTOMER-HSA-71387
Glycosaminoglycan metabolismREACTOMER-HSA-1630316
Chondroitin sulfate/dermatan sulfate metabolismREACTOMER-HSA-1793185
Dermatan sulfate biosynthesisREACTOMER-HSA-2022923

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
348152992022Clinical and molecular features of 66 patients with musculocontractural Ehlers-Danlos syndrome caused by pathogenic variants in CHST14 (mcEDS-CHST14).14
348152992022Clinical and molecular features of 66 patients with musculocontractural Ehlers-Danlos syndrome caused by pathogenic variants in CHST14 (mcEDS-CHST14).14
321307952020Delineation of musculocontractural Ehlers-Danlos Syndrome caused by dermatan sulfate epimerase deficiency.12
321307952020Delineation of musculocontractural Ehlers-Danlos Syndrome caused by dermatan sulfate epimerase deficiency.12
299767582018Dermatan sulfate epimerase 1 and dermatan 4-O-sulfotransferase 1 form complexes that generate long epimerized 4-O-sulfated blocks.17
301952692018Spinal manifestations in 12 patients with musculocontractural Ehlers-Danlos syndrome caused by CHST14/D4ST1 deficiency (mcEDS-CHST14).10
299767582018Dermatan sulfate epimerase 1 and dermatan 4-O-sulfotransferase 1 form complexes that generate long epimerized 4-O-sulfated blocks.17
301952692018Spinal manifestations in 12 patients with musculocontractural Ehlers-Danlos syndrome caused by CHST14/D4ST1 deficiency (mcEDS-CHST14).10
282388102017Defect in dermatan sulfate in urine of patients with Ehlers-Danlos syndrome caused by a CHST14/D4ST1 deficiency.17
282388102017Defect in dermatan sulfate in urine of patients with Ehlers-Danlos syndrome caused by a CHST14/D4ST1 deficiency.17
263736982016The phenotype of the musculocontractural type of Ehlers-Danlos syndrome due to CHST14 mutations.29
266466002016CHST14/D4ST1 deficiency: New form of Ehlers-Danlos syndrome.25
263736982016The phenotype of the musculocontractural type of Ehlers-Danlos syndrome due to CHST14 mutations.29
266466002016CHST14/D4ST1 deficiency: New form of Ehlers-Danlos syndrome.25
225814682012Extracellular matrix and platelet function in patients with musculocontractural Ehlers-Danlos syndrome caused by mutations in the CHST14 gene.12

Citation

Dessen P

CHST14 (carbohydrate sulfotransferase 14)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/61821/chst14-(carbohydrate-sulfotransferase-14)