CHST8 (carbohydrate sulfotransferase 8)

2014-11-01  

Identity

HGNC
LOCATION
19q13.11
LOCUSID
ALIAS
GALNAC4ST1,GalNAc4ST,PSS3
FUSION GENES

Other Information

Locus ID:

NCBI: 64377
MIM: 610190
HGNC: 15993
Ensembl: ENSG00000124302

Variants:

dbSNP: 64377
ClinVar: 64377
TCGA: ENSG00000124302
COSMIC: CHST8

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000124302ENST00000262622Q9H2A9
ENSG00000124302ENST00000434302Q9H2A9
ENSG00000124302ENST00000438847Q9H2A9
ENSG00000124302ENST00000591231K7ENM3
ENSG00000124302ENST00000650847Q9H2A9

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100

Pathways

PathwaySourceExternal ID
Metabolic pathwaysKEGGhsa01100
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Asparagine N-linked glycosylationREACTOMER-HSA-446203
Transport to the Golgi and subsequent modificationREACTOMER-HSA-948021
N-glycan antennae elongation in the medial/trans-GolgiREACTOMER-HSA-975576
Reactions specific to the complex N-glycan synthesis pathwayREACTOMER-HSA-975578

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
208161952010Analyses of shared genetic factors between asthma and obesity in children.43
222894162012Whole-exome sequencing in a single proband reveals a mutation in the CHST8 gene in autosomal recessive peeling skin syndrome.8
160794142005Differential expression and enzymatic properties of GalNAc-4-sulfotransferase-1 and GalNAc-4-sulfotransferase-2.3
282044962017The glycan-specific sulfotransferase (R77W)GalNAc-4-ST1 putatively responsible for peeling skin syndrome has normal properties consistent with a simple sequence polymorphisim.1

Citation

Dessen P

CHST8 (carbohydrate sulfotransferase 8)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/61826/chst8-(carbohydrate-sulfotransferase-8)