CLDN15 (claudin 15)

2014-11-01  

Identity

HGNC
CLDN15
LOCATION
7q22.1
LOCUSID
24146
ALIAS
-

Other Information

Locus ID:

NCBI: 24146
MIM: 615778
HGNC: 2036
Ensembl: ENSG00000106404

Variants:

dbSNP: 24146
ClinVar: 24146
TCGA: ENSG00000106404
COSMIC: CLDN15

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000106404ENST00000308344P56746
ENSG00000106404ENST00000401528P56746
ENSG00000106404ENST00000412417C9JHQ4
ENSG00000106404ENST00000414035C9J3Z2
ENSG00000106404ENST00000433833H7C2D7
ENSG00000106404ENST00000611078Q96FX9

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cell adhesion molecules (CAMs)KEGGko04514
Tight junctionKEGGko04530
Leukocyte transendothelial migrationKEGGko04670
Cell adhesion molecules (CAMs)KEGGhsa04514
Tight junctionKEGGhsa04530
Leukocyte transendothelial migrationKEGGhsa04670
Hepatitis CKEGGko05160
Hepatitis CKEGGhsa05160
Cell-Cell communicationREACTOMER-HSA-1500931
Cell junction organizationREACTOMER-HSA-446728
Cell-cell junction organizationREACTOMER-HSA-421270
Tight junction interactionsREACTOMER-HSA-420029

References

Pubmed IDYearTitleCitations
356506572022Tight junction channels claudin-10b and claudin-15: Functional mapping of pore-lining residues.8
361146742022Unique structural features of claudin-5 and claudin-15 lead to functionally distinct tight junction strand architecture.6
356506572022Tight junction channels claudin-10b and claudin-15: Functional mapping of pore-lining residues.8
361146742022Unique structural features of claudin-5 and claudin-15 lead to functionally distinct tight junction strand architecture.6
341311542021CLDN15 is a novel diagnostic marker for malignant pleural mesothelioma.9
341311542021CLDN15 is a novel diagnostic marker for malignant pleural mesothelioma.9
316050162020Differential regulation of claudin-2 and claudin-15 expression in children and adults with malabsorptive disease.15
324691522020Twist1 accelerates tumour vasculogenic mimicry by inhibiting Claudin15 expression in triple-negative breast cancer.6
316050162020Differential regulation of claudin-2 and claudin-15 expression in children and adults with malabsorptive disease.15
324691522020Twist1 accelerates tumour vasculogenic mimicry by inhibiting Claudin15 expression in triple-negative breast cancer.6
278697982017Gluten-induced symptoms in diarrhea-predominant irritable bowel syndrome are associated with increased myosin light chain kinase activity and claudin-15 expression.27
288631932017A refined model of claudin-15 tight junction paracellular architecture by molecular dynamics simulations.27
278697982017Gluten-induced symptoms in diarrhea-predominant irritable bowel syndrome are associated with increased myosin light chain kinase activity and claudin-15 expression.27
288631932017A refined model of claudin-15 tight junction paracellular architecture by molecular dynamics simulations.27

Citation

Dessen P

CLDN15 (claudin 15)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/61857/cldn15-(claudin-15)