CLIC2 (chloride intracellular channel 2)

2014-11-01 Affiliation

Identity

HGNC

CLIC2

LOCATION

Xq28

LOCUSID

1193

ALIAS

CLCNL2,CLIC2b,MRXS32,XAP121

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 1193
MIM: 300138
HGNC: 2063
Ensembl: ENSG00000155962

Variants:

dbSNP: 1193
ClinVar: 1193
TCGA: ENSG00000155962
COSMIC: CLIC2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000155962	ENST00000321926	A6PVS0
ENSG00000155962	ENST00000369449	O15247

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Muscle contraction	REACTOME	R-HSA-397014
Transmembrane transport of small molecules	REACTOME	R-HSA-382551
Ion channel transport	REACTOME	R-HSA-983712
Stimuli-sensing channels	REACTOME	R-HSA-2672351
Cardiac conduction	REACTOME	R-HSA-5576891
Ion homeostasis	REACTOME	R-HSA-5578775

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
34229297	2021	Chloride intracellular channel protein 2 is secreted and inhibits MMP14 activity, while preventing tumor cell invasion and metastasis.	8
34229297	2021	Chloride intracellular channel protein 2 is secreted and inhibits MMP14 activity, while preventing tumor cell invasion and metastasis.	8
29198705	2018	Tilapia and human CLIC2 structures are highly conserved.	3
29198705	2018	Tilapia and human CLIC2 structures are highly conserved.	3
22814392	2012	An X-linked channelopathy with cardiomegaly due to a CLIC2 mutation enhancing ryanodine receptor channel activity.	56
22814392	2012	An X-linked channelopathy with cardiomegaly due to a CLIC2 mutation enhancing ryanodine receptor channel activity.	56
18186468	2008	The crystal structure of human chloride intracellular channel protein 2: a disulfide bond with functional implications.	10
18186468	2008	The crystal structure of human chloride intracellular channel protein 2: a disulfide bond with functional implications.	10
17945253	2007	Structure of the Janus protein human CLIC2.	28
18007051	2007	Expression, purification, crystallization and preliminary X-ray diffraction analysis of chloride intracellular channel 2 (CLIC2).	2
17945253	2007	Structure of the Janus protein human CLIC2.	28
18007051	2007	Expression, purification, crystallization and preliminary X-ray diffraction analysis of chloride intracellular channel 2 (CLIC2).	2
15147738	2004	CLIC-2 modulates cardiac ryanodine receptor Ca2+ release channels.	22
15147738	2004	CLIC-2 modulates cardiac ryanodine receptor Ca2+ release channels.	22

Citation

Dessen P

CLIC2 (chloride intracellular channel 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/61884/gene-fusions/js/welcome