CLNS1A (chloride nucleotide-sensitive channel 1A)

2014-11-01  

Identity

HGNC
CLNS1A
LOCATION
11q14.1
LOCUSID
1207
ALIAS
CLCI,CLNS1B,ICln
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 1207
MIM: 602158
HGNC: 2080
Ensembl: ENSG00000074201

Variants:

dbSNP: 1207
ClinVar: 1207
TCGA: ENSG00000074201
COSMIC: CLNS1A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000074201ENST00000263309J3KN38
ENSG00000074201ENST00000525064E9PJF4
ENSG00000074201ENST00000525428P54105
ENSG00000074201ENST00000526009H0YEN9
ENSG00000074201ENST00000526761U3KPU0
ENSG00000074201ENST00000527133E9PQ83
ENSG00000074201ENST00000528364P54105
ENSG00000074201ENST00000532069E9PMI6

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
RNA transportKEGGko03013
RNA transportKEGGhsa03013
Gene ExpressionREACTOMER-HSA-74160
Metabolism of non-coding RNAREACTOMER-HSA-194441
snRNP AssemblyREACTOMER-HSA-191859

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
210815032011RioK1, a new interactor of protein arginine methyltransferase 5 (PRMT5), competes with pICln for binding and modulates PRMT5 complex composition and substrate specificity.45
150753262004ICln, a novel integrin alphaIIbbeta3-associated protein, functionally regulates platelet activation.14
160876812005Toward an assembly line for U7 snRNPs: interactions of U7-specific Lsm proteins with PRMT5 and SMN complexes.14
159051692005ICln159 folds into a pleckstrin homology domain-like structure. Interaction with kinases and the splicing factor LSm4.11
219179312011The molecular and functional interaction between ICln and HSPC038 proteins modulates the regulation of cell volume.6
149603052004Volume-regulated Cl- channels in human pleural mesothelioma cells.5
242980232014Characterization and in vivo functional analysis of the Schizosaccharomyces pombe ICLN gene.3

Citation

Dessen P

CLNS1A (chloride nucleotide-sensitive channel 1A)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/61898/clns1a-(chloride-nucleotide-sensitive-channel-1a)