CLSTN1 (calsyntenin 1)

2014-11-01  

Identity

HGNC
CLSTN1
LOCATION
1p36.22
LOCUSID
22883
ALIAS
ALC-ALPHA,CDHR12,CST-1,CSTN1,PIK3CD,XB31alpha,alcalpha1,alcalpha2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 22883
MIM: 611321
HGNC: 17447
Ensembl: ENSG00000171603

Variants:

dbSNP: 22883
ClinVar: 22883
TCGA: ENSG00000171603
COSMIC: CLSTN1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000171603ENST00000361311O94985
ENSG00000171603ENST00000377298O94985
ENSG00000171603ENST00000435891Q5SR54
ENSG00000171603ENST00000650348A0A3B3ITY6

Expression (GTEx)

0
50
100
150
200
250
300
350
400
450
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
215555182011The BTB and CNC homology 1 (BACH1) target genes are involved in the oxidative stress response and in control of the cell cycle.60
224348222012Calsyntenin-1 mediates axonal transport of the amyloid precursor protein and regulates Aβ production.46
150376142004Coordinated metabolism of Alcadein and amyloid beta-protein precursor regulates FE65-dependent gene transactivation.30
213858392011Phosphorylation of kinesin light chain 1 at serine 460 modulates binding and trafficking of calsyntenin-1.28
225719802012Potential utility of soluble p3-alcadein α plasma levels as a biomarker for sporadic Alzheimer's disease.4
243054992014Increased levels of plasma p3-alcα35, a major fragment of Alcadeinα by γ-secretase cleavage, in Alzheimer's disease.4
290930242017Phosphorylation of multiple sites within an acidic region of Alcadein α is required for kinesin-1 association and Golgi exit of Alcadein α cargo.3
272213182016Calsyntenin-1 mediates hepatitis C virus replication.1

Citation

Dessen P

CLSTN1 (calsyntenin 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/61907/clstn1-(calsyntenin-1)