COG1 (component of oligomeric golgi complex 1)

2014-11-01  

Identity

HGNC
LOCATION
17q25.1
LOCUSID
ALIAS
CDG2G,LDLB
FUSION GENES

Other Information

Locus ID:

NCBI: 9382
MIM: 606973
HGNC: 6545
Ensembl: ENSG00000166685

Variants:

dbSNP: 9382
ClinVar: 9382
TCGA: ENSG00000166685
COSMIC: COG1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000166685ENST00000299886Q8WTW3
ENSG00000166685ENST00000438720E9PBL8
ENSG00000166685ENST00000582512J3QLT5
ENSG00000166685ENST00000582587J3KRP4
ENSG00000166685ENST00000582672J3QKY9
ENSG00000166685ENST00000582973J3KSY3
ENSG00000166685ENST00000618996A0A087WVI0

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Asparagine N-linked glycosylationREACTOMER-HSA-446203
Transport to the Golgi and subsequent modificationREACTOMER-HSA-948021
ER to Golgi Anterograde TransportREACTOMER-HSA-199977
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
COPI-mediated anterograde transportREACTOMER-HSA-6807878
Intra-Golgi and retrograde Golgi-to-ER trafficREACTOMER-HSA-6811442
Retrograde transport at the Trans-Golgi-NetworkREACTOMER-HSA-6811440
Intra-Golgi trafficREACTOMER-HSA-6811438

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
168571842006IntraGolgi distribution of the Conserved Oligomeric Golgi (COG) complex.23
190082992009Cerebrocostomandibular-like syndrome and a mutation in the conserved oligomeric Golgi complex, subunit 1.12
119298782002Sec34 is implicated in traffic from the endoplasmic reticulum to the Golgi and exists in a complex with GTC-90 and ldlBp.8
271081902016Mass spectrometric analysis of host cell proteins interacting with dengue virus nonstructural protein 1 in dengue virus-infected HepG2 cells.3
274126792016Oxidative stress and hemoglobin-cholesterol adduct in renal patients with different LDL phenotypes.0

Citation

Dessen P

COG1 (component of oligomeric golgi complex 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/61975/cog1-(component-of-oligomeric-golgi-complex-1)