COMMD3 (COMM domain containing 3)

2014-11-01  

Identity

HGNC
COMMD3
LOCATION
10p12.2
LOCUSID
23412
ALIAS
BUP,C10orf8
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 23412
MIM: 616700
HGNC: 23332
Ensembl: ENSG00000148444

Variants:

dbSNP: 23412
ClinVar: 23412
TCGA: ENSG00000148444
COSMIC: COMMD3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000148444ENST00000376836Q9UBI1
ENSG00000148444ENST00000444869H0Y6Z9
ENSG00000148444ENST00000448361H0Y4E5
ENSG00000148444ENST00000456711H0Y4W0
ENSG00000148444ENST00000471350R4GNF2
ENSG00000148444ENST00000472610R4GN06

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
364453302023COMMD3-Mediated Endosomal Trafficking of HER2 Inhibits the Progression of Ovarian Carcinoma.1
370728582023COMMD3 loss drives invasive breast cancer growth by modulating copper homeostasis.4
364453302023COMMD3-Mediated Endosomal Trafficking of HER2 Inhibits the Progression of Ovarian Carcinoma.1
370728582023COMMD3 loss drives invasive breast cancer growth by modulating copper homeostasis.4
349056162022Syntaxin 12 and COMMD3 are new factors that function with VPS33B in the biogenesis of platelet α-granules.6
349056162022Syntaxin 12 and COMMD3 are new factors that function with VPS33B in the biogenesis of platelet α-granules.6
344932382021Transcriptional analysis of the expression, prognostic value and immune infiltration activities of the COMMD protein family in hepatocellular carcinoma.11
344932382021Transcriptional analysis of the expression, prognostic value and immune infiltration activities of the COMMD protein family in hepatocellular carcinoma.11
310888982019The COMMD3/8 complex determines GRK6 specificity for chemoattractant receptors.18
314671792019COMMD3:BMI1 Fusion and COMMD3 Protein Regulate C-MYC Transcription: Novel Therapeutic Target for Metastatic Prostate Cancer.16
310888982019The COMMD3/8 complex determines GRK6 specificity for chemoattractant receptors.18
314671792019COMMD3:BMI1 Fusion and COMMD3 Protein Regulate C-MYC Transcription: Novel Therapeutic Target for Metastatic Prostate Cancer.16

Citation

Dessen P

COMMD3 (COMM domain containing 3)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/62013/commd3-(comm-domain-containing-3)